Allelic diversity at the DLA-88 locus in Golden Retriever and Boxer breeds is limited

P. Ross, A. S. Buntzman, B. G. Vincent, E. N. Grover, G. S. Gojanovich, E. J. Collins, Jeffrey A Frelinger, P. R. Hess

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


In the dog, previous analyses of major histocompatibility complex class I genes suggest a single polymorphic locus, dog leukocyte antigen (DLA)-88. While 51 alleles have been reported, estimates of prevalence have not been made. We hypothesized that, within a breed, DLA-88 diversity would be restricted, and one or more dominant alleles could be identified. Accordingly, we determined allele usage in 47 Golden Retrievers and 39 Boxers. In each population, 10 alleles were found; 4 were shared. Seven novel alleles were identified. DLA-88*05101 and *50801 predominated in Golden Retrievers, while most Boxers carried *03401. In these breeds, DLA-88 polymorphisms are limited and largely non-overlapping. The finding of highly prevalent alleles fulfills an important prerequisite for studying canine CD8+ T-cell responses.

Original languageEnglish (US)
Pages (from-to)175-183
Number of pages9
JournalTissue Antigens
Issue number2
StatePublished - Aug 2012


  • Breeds
  • Canine
  • Class I genes
  • Major histocompatibility complex
  • Polymorphisms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics


Dive into the research topics of 'Allelic diversity at the DLA-88 locus in Golden Retriever and Boxer breeds is limited'. Together they form a unique fingerprint.

Cite this