Aldol reactions in multicomponent reaction based domino pathways: A multipurpose enabling tool in heterocyclic chemistry

Zhigang Xu; Fabio De Moliner; Alexandra P. Cappelli; Christopher Hulme

doi:10.1021/ol401068u

Aldol reactions in multicomponent reaction based domino pathways: A multipurpose enabling tool in heterocyclic chemistry

Zhigang Xu, Fabio De Moliner, Alexandra P. Cappelli, Christopher Hulme

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72 Scopus citations

Abstract

The aldol reaction has been evaluated in combination with the Ugi multicomponent reaction to assemble richly decorated mono- and polycyclic systems via expeditious cascade pathways. A small collection of pyrrolinones was generated thereof, and the scarcely accessible pyridoquinoxalinedione scaffold was also prepared by designing an additional nucleophilic substitution step in this domino sequence requiring minimal operational effort.

Original language	English (US)
Pages (from-to)	2738-2741
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	11
DOIs	https://doi.org/10.1021/ol401068u
State	Published - Jun 7 2013

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol401068u

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abstract = "The aldol reaction has been evaluated in combination with the Ugi multicomponent reaction to assemble richly decorated mono- and polycyclic systems via expeditious cascade pathways. A small collection of pyrrolinones was generated thereof, and the scarcely accessible pyridoquinoxalinedione scaffold was also prepared by designing an additional nucleophilic substitution step in this domino sequence requiring minimal operational effort.",

author = "Zhigang Xu and {De Moliner}, Fabio and Cappelli, {Alexandra P.} and Christopher Hulme",

year = "2013",

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AU - Xu, Zhigang

AU - De Moliner, Fabio

AU - Cappelli, Alexandra P.

AU - Hulme, Christopher

PY - 2013/6/7

Y1 - 2013/6/7

N2 - The aldol reaction has been evaluated in combination with the Ugi multicomponent reaction to assemble richly decorated mono- and polycyclic systems via expeditious cascade pathways. A small collection of pyrrolinones was generated thereof, and the scarcely accessible pyridoquinoxalinedione scaffold was also prepared by designing an additional nucleophilic substitution step in this domino sequence requiring minimal operational effort.

AB - The aldol reaction has been evaluated in combination with the Ugi multicomponent reaction to assemble richly decorated mono- and polycyclic systems via expeditious cascade pathways. A small collection of pyrrolinones was generated thereof, and the scarcely accessible pyridoquinoxalinedione scaffold was also prepared by designing an additional nucleophilic substitution step in this domino sequence requiring minimal operational effort.

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Aldol reactions in multicomponent reaction based domino pathways: A multipurpose enabling tool in heterocyclic chemistry

Abstract

ASJC Scopus subject areas

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