Understanding the mechanisms responsible for the development of chronic airflow obstruction is very important since this disease is the fifth leading cause of death in the United States and it produces a significant economic and social burden for society. Since reversal of established airflow obstruction is not possible, it would appear that the best prognosis and therapeutic results can be obtained by early diagnosis and prevention of irreversible disease. Understanding the underlying pathophysiologic mechanisms is necessary to detect susceptible individuals and develop effective interventions.
|Original language||English (US)|
|Number of pages||14|
|Journal||Agents and actions. Supplements|
|State||Published - 1990|
ASJC Scopus subject areas
- Pharmacology (medical)