AIDS-Kaposi's sarcoma complex: Evolution of a full-blown lymphologic syndrome

M. H. Witte, C. L. Witte

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A hypothesis is presented to explain the link between acquired immunodeficiency syndrome (AIDS) and Kaposi's sarcoma (KS). According to this hypothesis, AIDS involves all four components of the integrated lymphatic system-lymphatics, lymph nodes, lymphocytes, and lymph- and thereby resembles various congenital and acquired lymphologic syndromes characterized by one or more of the following features: lymphostasis, angiogenesis, and fibrosis; depletion of immunocompetent cells and immunosuppression; opportunistic infections; and vascular neoplasms. A better understanding of the steps in the evolution of these processes and their interrelationships to the four components of the lymphatic system should provide insight into the immunopathogenesis of AIDS-KS as well as its detection and treatment.

Original languageEnglish (US)
Pages (from-to)4-10
Number of pages7
Issue number1
StatePublished - 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology


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