Aging, persistent viral infections, and immunosenescence: Can exercise "make space"?

Richard J. Simpson

doi:10.1097/JES.0b013e318201f39d

Aging, persistent viral infections, and immunosenescence: Can exercise "make space"?

Richard J. Simpson

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Overcrowding the immune space with excess clones of viral-specific T cells causes the naïve T-cell repertoire to shrink, which increases infection susceptibility to novel pathogens. Physical exercise preferentially mobilizes senescent T cells from the peripheral tissues into the blood, which might facilitate their subsequent apoptosis and create "vacant space" for newly functional T cells to occupy and expand the naïve T-cell repertoire.

Original language	English (US)
Pages (from-to)	23-33
Number of pages	11
Journal	Exercise and Sport Sciences Reviews
Volume	39
Issue number	1
DOIs	https://doi.org/10.1097/JES.0b013e318201f39d
State	Published - Jan 2011
Externally published	Yes

Keywords

cytomegalovirus
immune risk profile
immunology
lymphocyte apoptosis
T cell

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

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10.1097/JES.0b013e318201f39d

Cite this

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title = "Aging, persistent viral infections, and immunosenescence: Can exercise {"}make space{"}?",

abstract = "Overcrowding the immune space with excess clones of viral-specific T cells causes the na{\"i}ve T-cell repertoire to shrink, which increases infection susceptibility to novel pathogens. Physical exercise preferentially mobilizes senescent T cells from the peripheral tissues into the blood, which might facilitate their subsequent apoptosis and create {"}vacant space{"} for newly functional T cells to occupy and expand the na{\"i}ve T-cell repertoire.",

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AB - Overcrowding the immune space with excess clones of viral-specific T cells causes the naïve T-cell repertoire to shrink, which increases infection susceptibility to novel pathogens. Physical exercise preferentially mobilizes senescent T cells from the peripheral tissues into the blood, which might facilitate their subsequent apoptosis and create "vacant space" for newly functional T cells to occupy and expand the naïve T-cell repertoire.

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KW - immunology

KW - lymphocyte apoptosis

KW - T cell

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Aging, persistent viral infections, and immunosenescence: Can exercise "make space"?

Abstract

Keywords

ASJC Scopus subject areas

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