Aging, persistent viral infections, and immunosenescence: Can exercise "make space"?

Research output: Contribution to journalArticlepeer-review

114 Scopus citations


Overcrowding the immune space with excess clones of viral-specific T cells causes the naïve T-cell repertoire to shrink, which increases infection susceptibility to novel pathogens. Physical exercise preferentially mobilizes senescent T cells from the peripheral tissues into the blood, which might facilitate their subsequent apoptosis and create "vacant space" for newly functional T cells to occupy and expand the naïve T-cell repertoire.

Original languageEnglish (US)
Pages (from-to)23-33
Number of pages11
JournalExercise and Sport Sciences Reviews
Issue number1
StatePublished - Jan 2011
Externally publishedYes


  • T cell
  • cytomegalovirus
  • immune risk profile
  • immunology
  • lymphocyte apoptosis

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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