Aging of the immune system across different species

Janko Nikolich-Žugich, Luka Čičin-Šain

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations


Aging of the immune system, called immunosenescence, has been linked to reduced ability to resist infection, and increased mortality and morbidity from infectious diseases, which consistently rank in the top five causes of death in the old age, even in industrial societies. This review summarizes our knowledge about the evolution of the innate and adaptive immune systems in light of the longevity of the organism, as well as the current state of our understanding of age-related changes in each of the arms of the immune system in various model organisms. It is clear that adaptive immunity, which we propose evolved as an essential function that provides longevity, eventually erodes in the old age. The jury is still out as to whether innate immunity undergoes a similar decay, whether it stays the same, or whether, perhaps, it is able to compensate for the loss of adaptive immune function.

Original languageEnglish (US)
Title of host publicationThe Comparative Biology of Aging
PublisherSpringer Netherlands
Number of pages24
ISBN (Print)9789048134649
StatePublished - 2010


  • Adaptive immunity
  • Immune senescence
  • Immunity
  • Innate immune system

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences


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