Aging immunity and the impact of physical exercise

Guillaume Spielmann; Austin B. Bigley; Emily C. Lavoy; Richard J. Simpson

doi:10.1007/978-3-642-39495-9_26

Aging immunity and the impact of physical exercise

Guillaume Spielmann, Austin B. Bigley, Emily C. Lavoy, Richard J. Simpson

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Regular physical exercise is associated with increased longevity and a lower risk of developing several age-associated diseases. In addition, regular exercise has been purported as a simple lifestyle intervention to counteract the deleterious effects of age-associated changes in immunity known as immunosenescence. Etiology of immunosenescence is multifaceted and can impact on both arms of the immune system. Since 1990, several longitudinal ageing studies using aerobic- and/or resistance-based exercise provided growing information on the benefits of exercise in both innate immunity and adaptive immunity. Regular exercise can improve responses to vaccines, NK-cell function, neutrophil phagocytic activity, and T-cell proliferation. It also reduces circulatory inflammatory mediators and inflammatory response to bacterial challenge. These findings provide a strong indication that habitual exercise has immune regulatory properties and may help delay the onset of immunosenescence.

Original language	English (US)
Title of host publication	Immunology of Aging
Publisher	Springer-Verlag Berlin Heidelberg
Pages	369-397
Number of pages	29
ISBN (Electronic)	9783642394959
ISBN (Print)	3642394949, 9783642394942
DOIs	https://doi.org/10.1007/978-3-642-39495-9_26
State	Published - Jan 1 2014
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-3-642-39495-9_26

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abstract = "Regular physical exercise is associated with increased longevity and a lower risk of developing several age-associated diseases. In addition, regular exercise has been purported as a simple lifestyle intervention to counteract the deleterious effects of age-associated changes in immunity known as immunosenescence. Etiology of immunosenescence is multifaceted and can impact on both arms of the immune system. Since 1990, several longitudinal ageing studies using aerobic- and/or resistance-based exercise provided growing information on the benefits of exercise in both innate immunity and adaptive immunity. Regular exercise can improve responses to vaccines, NK-cell function, neutrophil phagocytic activity, and T-cell proliferation. It also reduces circulatory inflammatory mediators and inflammatory response to bacterial challenge. These findings provide a strong indication that habitual exercise has immune regulatory properties and may help delay the onset of immunosenescence.",

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AB - Regular physical exercise is associated with increased longevity and a lower risk of developing several age-associated diseases. In addition, regular exercise has been purported as a simple lifestyle intervention to counteract the deleterious effects of age-associated changes in immunity known as immunosenescence. Etiology of immunosenescence is multifaceted and can impact on both arms of the immune system. Since 1990, several longitudinal ageing studies using aerobic- and/or resistance-based exercise provided growing information on the benefits of exercise in both innate immunity and adaptive immunity. Regular exercise can improve responses to vaccines, NK-cell function, neutrophil phagocytic activity, and T-cell proliferation. It also reduces circulatory inflammatory mediators and inflammatory response to bacterial challenge. These findings provide a strong indication that habitual exercise has immune regulatory properties and may help delay the onset of immunosenescence.

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Aging immunity and the impact of physical exercise

Abstract

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