Aging immunity and the impact of physical exercise

Guillaume Spielmann; Austin B. Bigley; Emily C. Lavoy; Richard J. Simpson

doi:10.1007/978-3-642-39495-9_26

Aging immunity and the impact of physical exercise

Guillaume Spielmann, Austin B. Bigley, Emily C. Lavoy, Richard J. Simpson

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Regular physical exercise is associated with increased longevity and a lower risk of developing several age-associated diseases. In addition, regular exercise has been purported as a simple lifestyle intervention to counteract the deleterious effects of age-associated changes in immunity known as immunosenescence. Etiology of immunosenescence is multifaceted and can impact on both arms of the immune system. Since 1990, several longitudinal ageing studies using aerobic- and/or resistance-based exercise provided growing information on the benefits of exercise in both innate immunity and adaptive immunity. Regular exercise can improve responses to vaccines, NK-cell function, neutrophil phagocytic activity, and T-cell proliferation. It also reduces circulatory inflammatory mediators and inflammatory response to bacterial challenge. These findings provide a strong indication that habitual exercise has immune regulatory properties and may help delay the onset of immunosenescence.

Original language	English (US)
Title of host publication	Immunology of Aging
Publisher	Springer-Verlag Berlin Heidelberg
Pages	369-397
Number of pages	29
ISBN (Electronic)	9783642394959
ISBN (Print)	3642394949, 9783642394942
DOIs	https://doi.org/10.1007/978-3-642-39495-9_26
State	Published - Jan 1 2014
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Access to Document

10.1007/978-3-642-39495-9_26

Cite this

@inbook{e4e3ed1a432d4b3783375dfe51af5bc2,

title = "Aging immunity and the impact of physical exercise",

abstract = "Regular physical exercise is associated with increased longevity and a lower risk of developing several age-associated diseases. In addition, regular exercise has been purported as a simple lifestyle intervention to counteract the deleterious effects of age-associated changes in immunity known as immunosenescence. Etiology of immunosenescence is multifaceted and can impact on both arms of the immune system. Since 1990, several longitudinal ageing studies using aerobic- and/or resistance-based exercise provided growing information on the benefits of exercise in both innate immunity and adaptive immunity. Regular exercise can improve responses to vaccines, NK-cell function, neutrophil phagocytic activity, and T-cell proliferation. It also reduces circulatory inflammatory mediators and inflammatory response to bacterial challenge. These findings provide a strong indication that habitual exercise has immune regulatory properties and may help delay the onset of immunosenescence.",

author = "Guillaume Spielmann and Bigley, {Austin B.} and Lavoy, {Emily C.} and Simpson, {Richard J.}",

note = "Publisher Copyright: {\textcopyright} 2014 Springer-Verlag Berlin Heidelberg. All rights are reserved.",

year = "2014",

month = jan,

day = "1",

doi = "10.1007/978-3-642-39495-9_26",

language = "English (US)",

isbn = "3642394949",

pages = "369--397",

booktitle = "Immunology of Aging",

publisher = "Springer-Verlag Berlin Heidelberg",

}

TY - CHAP

T1 - Aging immunity and the impact of physical exercise

AU - Spielmann, Guillaume

AU - Bigley, Austin B.

AU - Lavoy, Emily C.

AU - Simpson, Richard J.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Regular physical exercise is associated with increased longevity and a lower risk of developing several age-associated diseases. In addition, regular exercise has been purported as a simple lifestyle intervention to counteract the deleterious effects of age-associated changes in immunity known as immunosenescence. Etiology of immunosenescence is multifaceted and can impact on both arms of the immune system. Since 1990, several longitudinal ageing studies using aerobic- and/or resistance-based exercise provided growing information on the benefits of exercise in both innate immunity and adaptive immunity. Regular exercise can improve responses to vaccines, NK-cell function, neutrophil phagocytic activity, and T-cell proliferation. It also reduces circulatory inflammatory mediators and inflammatory response to bacterial challenge. These findings provide a strong indication that habitual exercise has immune regulatory properties and may help delay the onset of immunosenescence.

AB - Regular physical exercise is associated with increased longevity and a lower risk of developing several age-associated diseases. In addition, regular exercise has been purported as a simple lifestyle intervention to counteract the deleterious effects of age-associated changes in immunity known as immunosenescence. Etiology of immunosenescence is multifaceted and can impact on both arms of the immune system. Since 1990, several longitudinal ageing studies using aerobic- and/or resistance-based exercise provided growing information on the benefits of exercise in both innate immunity and adaptive immunity. Regular exercise can improve responses to vaccines, NK-cell function, neutrophil phagocytic activity, and T-cell proliferation. It also reduces circulatory inflammatory mediators and inflammatory response to bacterial challenge. These findings provide a strong indication that habitual exercise has immune regulatory properties and may help delay the onset of immunosenescence.

UR - http://www.scopus.com/inward/record.url?scp=84930244764&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930244764&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-39495-9_26

DO - 10.1007/978-3-642-39495-9_26

M3 - Chapter

AN - SCOPUS:84930244764

SN - 3642394949

SN - 9783642394942

SP - 369

EP - 397

BT - Immunology of Aging

PB - Springer-Verlag Berlin Heidelberg

ER -

Aging immunity and the impact of physical exercise

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this