Age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in Alzheimer's disease

Harald Hampel; Stefan J. Teipel; Wolfram Bayer; Gene E. Alexander; Robert Schwarz; Mark B. Schapiro; Stanley I. Rapoport; Hans Jürgen Möller

doi:10.1016/S0022-510X(01)00669-4

Age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in Alzheimer's disease

Harald Hampel, Stefan J. Teipel, Wolfram Bayer, Gene E. Alexander, Robert Schwarz, Mark B. Schapiro, Stanley I. Rapoport, Hans Jürgen Möller

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Objective: The specificity of magnetic resonance imaging (MRI)-based hippocampal measurements in detecting Alzheimer's disease (AD) pathology is reduced by an age-related reduction of the hippocampus volume. We propose an adjustment for this age effect to increase the diagnostic accuracy of hippocampal volumes in AD. Method: Using an orthogonal rotational transformation of the coordinate system, values of MRI-determined volumes of hippocampus-amygdala formation (HAF) were transformed according to the age effect in 27 AD patients and 28 age- and sex-matched healthy control subjects. Results: The age transformation increased the diagnostic accuracy of HAF volumes in the study sample and in an independent sample from the literature. The age-transformed HAF volume predicted AD in a subject with mild cognitive impairment (MCI) with later biopsy-confirmed AD. Conclusion: Age transformation may provide an easily applicable method to increase the clinical diagnostic accuracy of hippocampal measurements by considering the effect of aging on hippocampus volume.

Original language	English (US)
Pages (from-to)	15-19
Number of pages	5
Journal	Journal of the Neurological Sciences
Volume	194
Issue number	1
DOIs	https://doi.org/10.1016/S0022-510X(01)00669-4
State	Published - Feb 15 2002

Keywords

Age-transformation
Alzheimer's disease
Diagnosis
Discriminant analysis
Hippocampus
Magnetic resonance imaging
ROC analysis

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/S0022-510X(01)00669-4

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title = "Age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in Alzheimer's disease",

abstract = "Objective: The specificity of magnetic resonance imaging (MRI)-based hippocampal measurements in detecting Alzheimer's disease (AD) pathology is reduced by an age-related reduction of the hippocampus volume. We propose an adjustment for this age effect to increase the diagnostic accuracy of hippocampal volumes in AD. Method: Using an orthogonal rotational transformation of the coordinate system, values of MRI-determined volumes of hippocampus-amygdala formation (HAF) were transformed according to the age effect in 27 AD patients and 28 age- and sex-matched healthy control subjects. Results: The age transformation increased the diagnostic accuracy of HAF volumes in the study sample and in an independent sample from the literature. The age-transformed HAF volume predicted AD in a subject with mild cognitive impairment (MCI) with later biopsy-confirmed AD. Conclusion: Age transformation may provide an easily applicable method to increase the clinical diagnostic accuracy of hippocampal measurements by considering the effect of aging on hippocampus volume.",

keywords = "Age-transformation, Alzheimer's disease, Diagnosis, Discriminant analysis, Hippocampus, Magnetic resonance imaging, ROC analysis",

author = "Harald Hampel and Teipel, {Stefan J.} and Wolfram Bayer and Alexander, {Gene E.} and Robert Schwarz and Schapiro, {Mark B.} and Rapoport, {Stanley I.} and M{\"o}ller, {Hans J{\"u}rgen}",

note = "Funding Information: Part of this work was supported by a grant of Eisai (Frankfurt) and Pfizer (Karlsruhe), Germany, to H.H. and S.J.T and by a grant of the Medical Faculty of the Ludwig-Maximilian University, Munich, Germany, to S.J.T. ",

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language = "English (US)",

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T1 - Age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in Alzheimer's disease

AU - Hampel, Harald

AU - Teipel, Stefan J.

AU - Bayer, Wolfram

AU - Alexander, Gene E.

AU - Schwarz, Robert

AU - Schapiro, Mark B.

AU - Rapoport, Stanley I.

AU - Möller, Hans Jürgen

N1 - Funding Information: Part of this work was supported by a grant of Eisai (Frankfurt) and Pfizer (Karlsruhe), Germany, to H.H. and S.J.T and by a grant of the Medical Faculty of the Ludwig-Maximilian University, Munich, Germany, to S.J.T.

PY - 2002/2/15

Y1 - 2002/2/15

N2 - Objective: The specificity of magnetic resonance imaging (MRI)-based hippocampal measurements in detecting Alzheimer's disease (AD) pathology is reduced by an age-related reduction of the hippocampus volume. We propose an adjustment for this age effect to increase the diagnostic accuracy of hippocampal volumes in AD. Method: Using an orthogonal rotational transformation of the coordinate system, values of MRI-determined volumes of hippocampus-amygdala formation (HAF) were transformed according to the age effect in 27 AD patients and 28 age- and sex-matched healthy control subjects. Results: The age transformation increased the diagnostic accuracy of HAF volumes in the study sample and in an independent sample from the literature. The age-transformed HAF volume predicted AD in a subject with mild cognitive impairment (MCI) with later biopsy-confirmed AD. Conclusion: Age transformation may provide an easily applicable method to increase the clinical diagnostic accuracy of hippocampal measurements by considering the effect of aging on hippocampus volume.

AB - Objective: The specificity of magnetic resonance imaging (MRI)-based hippocampal measurements in detecting Alzheimer's disease (AD) pathology is reduced by an age-related reduction of the hippocampus volume. We propose an adjustment for this age effect to increase the diagnostic accuracy of hippocampal volumes in AD. Method: Using an orthogonal rotational transformation of the coordinate system, values of MRI-determined volumes of hippocampus-amygdala formation (HAF) were transformed according to the age effect in 27 AD patients and 28 age- and sex-matched healthy control subjects. Results: The age transformation increased the diagnostic accuracy of HAF volumes in the study sample and in an independent sample from the literature. The age-transformed HAF volume predicted AD in a subject with mild cognitive impairment (MCI) with later biopsy-confirmed AD. Conclusion: Age transformation may provide an easily applicable method to increase the clinical diagnostic accuracy of hippocampal measurements by considering the effect of aging on hippocampus volume.

KW - Age-transformation

KW - Alzheimer's disease

KW - Diagnosis

KW - Discriminant analysis

KW - Hippocampus

KW - Magnetic resonance imaging

KW - ROC analysis

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Age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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