TY - JOUR
T1 - Age-specific prevalence, incidence, and duration of human papillomavirus infections in a cohort of 290 US men
AU - Giuliano, Anna R.
AU - Lu, Beibei
AU - Nielson, Carrie M.
AU - Flores, Roberto
AU - Papenfuss, Mary R.
AU - Lee, Ji Hyun
AU - Abrahamsen, Martha
AU - Harris, Robin B.
N1 - Funding Information:
Financial support: Arizona Disease Control Research Commission (contract 7016; funding period, 2003–2006). Digene donated specimen transport medium, and Roche donated reagents for HPV detection.
PY - 2008/9/15
Y1 - 2008/9/15
N2 - Background. Human papillomavirus (HPV) infections cause disease in men and women, and male-to-female HPVtransmission influences the risk of cancer in females. The purpose of the present study was to describe the overall and age-specific incidence and clearance of HPV infections in men. Methods. In a prospective cohort study of 290 men aged 18-44 years, participants were examined at baseline and every 6 months, with a mean duration of follow-up of 15.5 months. Results. The period prevalence was 52.8% for any, 31.7% for oncogenic, and 30.0% for nononcogenic HPV infection. The 12-month cumulative risk of acquiring a new HPV infection was 29.2%. Incidences of HPV types 6, 11, 16, and 18 were 2.8, 0.5, 4.8, and 0.8 per 1000 person-months, respectively. The median time to clearance of any HPV infection was 5.9 months (95% confidence interval, 5.7- 6.1 months), with comparable times to clearance for oncogenic and nononcogenic infections. Approximately 75% of men tested negative for any HPV 12 months after initial HPV detection. Age was not significantly associated with HPV incidence or duration of infection in men. Conclusion. HPV infection in men was common, with relatively rapid rates of acquisition and clearance.
AB - Background. Human papillomavirus (HPV) infections cause disease in men and women, and male-to-female HPVtransmission influences the risk of cancer in females. The purpose of the present study was to describe the overall and age-specific incidence and clearance of HPV infections in men. Methods. In a prospective cohort study of 290 men aged 18-44 years, participants were examined at baseline and every 6 months, with a mean duration of follow-up of 15.5 months. Results. The period prevalence was 52.8% for any, 31.7% for oncogenic, and 30.0% for nononcogenic HPV infection. The 12-month cumulative risk of acquiring a new HPV infection was 29.2%. Incidences of HPV types 6, 11, 16, and 18 were 2.8, 0.5, 4.8, and 0.8 per 1000 person-months, respectively. The median time to clearance of any HPV infection was 5.9 months (95% confidence interval, 5.7- 6.1 months), with comparable times to clearance for oncogenic and nononcogenic infections. Approximately 75% of men tested negative for any HPV 12 months after initial HPV detection. Age was not significantly associated with HPV incidence or duration of infection in men. Conclusion. HPV infection in men was common, with relatively rapid rates of acquisition and clearance.
UR - http://www.scopus.com/inward/record.url?scp=51749089550&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51749089550&partnerID=8YFLogxK
U2 - 10.1086/591095
DO - 10.1086/591095
M3 - Article
C2 - 18657037
AN - SCOPUS:51749089550
SN - 0022-1899
VL - 198
SP - 827
EP - 835
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -