African-American heredity prostate cancer study: A model for genetic research

Issac J. Powell, John Carpten, Georgia Dunston, Rick Kittles, James Bennett, G. Hoke, Curtis Pettaway, Sally Weinrich, Srinivasan Vijayakumar, Chiledum A. Ahaghotu, William Boykin, Terry Mason, Charmaine Royal, Agnes Baffoe-Bonnie, John Bailey-Wilson, Kate Berg, Jeffrey Trent, Francis Collins

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


A genome-wide scan of high-risk prostate cancer families in North America has demonstrated linkage of a particular marker to Chromosome 1q (HPC1). An even greater proportion of African-American families have shown linkage to HPC1. Therefore, investigators at the National Human Genome Research Institute (NHGRI) in collaboration with Howard University and a predominantly African-American group of urologists established the African-American Hereditary Prostate Cancer (AAHPC) Study Network to confirm the suggested linkage of HPC in African Americans with a gene on Chromosome 1. Blood samples from recruited families were sent to Howard University for extraction of DNA. The DNA was sent to NHGRI at NIH where the genotyping and genetic sequence analysis was conducted. Genotype data are merged with pedigree information so that statistical analysis can be performed to establish potential linkage. From March 1, 1998, to June 1, 1999, a total of 40 African-American families have been recruited who met the study criteria. Preliminary results suggest that racial/ethnicity grouping may affect the incidence and extent of linkage of prostate cancer to specific loci. The importance of these findings lays in the future treatment of genetic-based diseases.

Original languageEnglish (US)
Pages (from-to)120-123
Number of pages4
JournalJournal of the National Medical Association
Issue number4
StatePublished - Apr 2001


  • Ethnicity
  • Genetics
  • Human genome project
  • Oncology
  • Prostate cancer

ASJC Scopus subject areas

  • General Medicine


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