Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses

Rachel Wong, Julia A. Belk, Jennifer Govero, Jennifer L. Uhrlaub, Dakota Reinartz, Haiyan Zhao, John M. Errico, Lucas D'Souza, Tyler J. Ripperger, Janko Nikolich-Zugich, Mark J. Shlomchik, Ansuman T. Satpathy, Daved H. Fremont, Michael S. Diamond, Deepta Bhattacharya

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Memory B cells respond to heterologous antigens either by molding new specificities through secondary germinal centers or by selecting preexisting clones without further affinity maturation. Wong et al. show that for flavivirus challenges, secondary germinal centers minimally contribute to recall responses. Instead, preexisting cross-reactive clones are selected from a diverse memory compartment.

Original languageEnglish (US)
Pages (from-to)1078-1094.e7
Issue number5
StatePublished - Nov 17 2020


  • Dengue virus
  • Japanese Encephalitis virus
  • West Nile virus
  • Zika virus
  • flaviruses
  • germinal center
  • memory B cells
  • plasma cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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