Advances in positive airway pressure treatment modalities for hypoventilation syndromes

Daniel Combs, Safal Shetty, Sairam Parthasarathy

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


The physiologic rationale for advanced PAP modalities is sound considering the complexity of sleep-disordered breathing in patients with hypoventilation syndromes. Various advanced PAP devices are available to assist breathing during sleep and wakefulness in patients with hypoventilation syndromes. Although such devices are increasingly used in clinical practice, the supporting clinical evidence warranting the use of such devices needs further study. Currently, there is an evolving body of literature that supports the beneficial effect of advanced PAP modalities on HR-QOL, physiologic endpoints, and even mortality. However, more comparative effectiveness research of such advanced PAP modality devices against conventional CPAP therapy in "realworld" situations and without the requirement of titration polysomnography need to be conducted. Moreover, there is much opportunity for further refining these devices, including the ability of the device to reliably monitor gas exchange, sleep- wakefulness state, and reducing variability in device efficacy owing to provider-selected device settings.

Original languageEnglish (US)
Pages (from-to)315-325
Number of pages11
JournalSleep Medicine Clinics
Issue number3
StatePublished - Sep 2014


  • Algorithms
  • Artificial respiration
  • Continuous positive airway pressure
  • Hypoventilation syndrome
  • Obesity
  • Obstructive sleep apnea
  • Positive airway pressure
  • Sleep

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health


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