Advanced MR imaging of acute stroke: The University of California at Los Angeles endovascular therapy experience

David S. Liebeskind; Chelsea S. Kidwell; Jeffry R. Alger; Gary R. Duckwiler; Y. Pierre Gobin; Reza Jahan; Bruce Ovbiagele; Jeffrey L. Saver; Sidney Starkman; Paul M. Vespa; J. Pablo Villablanca; Fernando Viñuela

doi:10.1016/j.nic.2005.06.002

Advanced MR imaging of acute stroke: The University of California at Los Angeles endovascular therapy experience

David S. Liebeskind, Chelsea S. Kidwell, Jeffry R. Alger, Gary R. Duckwiler, Y. Pierre Gobin, Reza Jahan, Bruce Ovbiagele, Jeffrey L. Saver, Sidney Starkman, Paul M. Vespa, J. Pablo Villablanca, Fernando Viñuela

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

An intensive early imaging approach using MR imaging before intra-arterial thrombolysis has provided considerable information regarding acute ischemic stroke, including the dynamic aspects of diffusion and perfusion abnormalities. Simple paradigms, such as diffusion-perfusion mismatch, have been transformed into refined models that estimate the extent of ischemic core and penumbra. MR imaging has also been advanced for the detection of intracranial hemorrhage, and may serve as the sole imaging modality before thrombolysis. Angiographic correlation at the time of thrombolysis has provided unique insight, delineating vascular correlates, including the degree of proximal arterial patency with recanalization and the extent of collateral flow. Although multivariate MR imaging models await prospective validation, these models may ultimately be used to optimize selection of ideal thrombolytic candidates.

Original language	English (US)
Pages (from-to)	455-466
Number of pages	12
Journal	Neuroimaging Clinics of North America
Volume	15
Issue number	2
DOIs	https://doi.org/10.1016/j.nic.2005.06.002
State	Published - May 2005

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology

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Liebeskind, D. S., Kidwell, C. S., Alger, J. R., Duckwiler, G. R., Gobin, Y. P., Jahan, R., Ovbiagele, B., Saver, J. L., Starkman, S., Vespa, P. M., Villablanca, J. P., & Viñuela, F. (2005). Advanced MR imaging of acute stroke: The University of California at Los Angeles endovascular therapy experience. Neuroimaging Clinics of North America, 15(2), 455-466. https://doi.org/10.1016/j.nic.2005.06.002

Liebeskind, DS, Kidwell, CS, Alger, JR, Duckwiler, GR, Gobin, YP, Jahan, R, Ovbiagele, B, Saver, JL, Starkman, S, Vespa, PM, Villablanca, JP & Viñuela, F 2005, 'Advanced MR imaging of acute stroke: The University of California at Los Angeles endovascular therapy experience', Neuroimaging Clinics of North America, vol. 15, no. 2, pp. 455-466. https://doi.org/10.1016/j.nic.2005.06.002

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title = "Advanced MR imaging of acute stroke: The University of California at Los Angeles endovascular therapy experience",

abstract = "An intensive early imaging approach using MR imaging before intra-arterial thrombolysis has provided considerable information regarding acute ischemic stroke, including the dynamic aspects of diffusion and perfusion abnormalities. Simple paradigms, such as diffusion-perfusion mismatch, have been transformed into refined models that estimate the extent of ischemic core and penumbra. MR imaging has also been advanced for the detection of intracranial hemorrhage, and may serve as the sole imaging modality before thrombolysis. Angiographic correlation at the time of thrombolysis has provided unique insight, delineating vascular correlates, including the degree of proximal arterial patency with recanalization and the extent of collateral flow. Although multivariate MR imaging models await prospective validation, these models may ultimately be used to optimize selection of ideal thrombolytic candidates.",

author = "Liebeskind, {David S.} and Kidwell, {Chelsea S.} and Alger, {Jeffry R.} and Duckwiler, {Gary R.} and Gobin, {Y. Pierre} and Reza Jahan and Bruce Ovbiagele and Saver, {Jeffrey L.} and Sidney Starkman and Vespa, {Paul M.} and Villablanca, {J. Pablo} and Fernando Vi{\~n}uela",

note = "Funding Information: This work was supported in part by grants from the American Heart Association (0170033N, CSK) and National Institute of Neurological Disorders and Stroke (K23 NS 02088, CSK; NS 39498/EB 002087, JRA; K24 NS 02092, JLS). ",

year = "2005",

month = may,

doi = "10.1016/j.nic.2005.06.002",

language = "English (US)",

volume = "15",

pages = "455--466",

journal = "Neuroimaging Clinics of North America",

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T1 - Advanced MR imaging of acute stroke

T2 - The University of California at Los Angeles endovascular therapy experience

AU - Liebeskind, David S.

AU - Kidwell, Chelsea S.

AU - Alger, Jeffry R.

AU - Duckwiler, Gary R.

AU - Gobin, Y. Pierre

AU - Jahan, Reza

AU - Ovbiagele, Bruce

AU - Saver, Jeffrey L.

AU - Starkman, Sidney

AU - Vespa, Paul M.

AU - Villablanca, J. Pablo

AU - Viñuela, Fernando

N1 - Funding Information: This work was supported in part by grants from the American Heart Association (0170033N, CSK) and National Institute of Neurological Disorders and Stroke (K23 NS 02088, CSK; NS 39498/EB 002087, JRA; K24 NS 02092, JLS).

PY - 2005/5

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N2 - An intensive early imaging approach using MR imaging before intra-arterial thrombolysis has provided considerable information regarding acute ischemic stroke, including the dynamic aspects of diffusion and perfusion abnormalities. Simple paradigms, such as diffusion-perfusion mismatch, have been transformed into refined models that estimate the extent of ischemic core and penumbra. MR imaging has also been advanced for the detection of intracranial hemorrhage, and may serve as the sole imaging modality before thrombolysis. Angiographic correlation at the time of thrombolysis has provided unique insight, delineating vascular correlates, including the degree of proximal arterial patency with recanalization and the extent of collateral flow. Although multivariate MR imaging models await prospective validation, these models may ultimately be used to optimize selection of ideal thrombolytic candidates.

AB - An intensive early imaging approach using MR imaging before intra-arterial thrombolysis has provided considerable information regarding acute ischemic stroke, including the dynamic aspects of diffusion and perfusion abnormalities. Simple paradigms, such as diffusion-perfusion mismatch, have been transformed into refined models that estimate the extent of ischemic core and penumbra. MR imaging has also been advanced for the detection of intracranial hemorrhage, and may serve as the sole imaging modality before thrombolysis. Angiographic correlation at the time of thrombolysis has provided unique insight, delineating vascular correlates, including the degree of proximal arterial patency with recanalization and the extent of collateral flow. Although multivariate MR imaging models await prospective validation, these models may ultimately be used to optimize selection of ideal thrombolytic candidates.

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Advanced MR imaging of acute stroke: The University of California at Los Angeles endovascular therapy experience

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