TY - JOUR
T1 - Advanced MR imaging of acute stroke
T2 - The University of California at Los Angeles endovascular therapy experience
AU - Liebeskind, David S.
AU - Kidwell, Chelsea S.
AU - Alger, Jeffry R.
AU - Duckwiler, Gary R.
AU - Gobin, Y. Pierre
AU - Jahan, Reza
AU - Ovbiagele, Bruce
AU - Saver, Jeffrey L.
AU - Starkman, Sidney
AU - Vespa, Paul M.
AU - Villablanca, J. Pablo
AU - Viñuela, Fernando
N1 - Funding Information:
This work was supported in part by grants from the American Heart Association (0170033N, CSK) and National Institute of Neurological Disorders and Stroke (K23 NS 02088, CSK; NS 39498/EB 002087, JRA; K24 NS 02092, JLS).
PY - 2005/5
Y1 - 2005/5
N2 - An intensive early imaging approach using MR imaging before intra-arterial thrombolysis has provided considerable information regarding acute ischemic stroke, including the dynamic aspects of diffusion and perfusion abnormalities. Simple paradigms, such as diffusion-perfusion mismatch, have been transformed into refined models that estimate the extent of ischemic core and penumbra. MR imaging has also been advanced for the detection of intracranial hemorrhage, and may serve as the sole imaging modality before thrombolysis. Angiographic correlation at the time of thrombolysis has provided unique insight, delineating vascular correlates, including the degree of proximal arterial patency with recanalization and the extent of collateral flow. Although multivariate MR imaging models await prospective validation, these models may ultimately be used to optimize selection of ideal thrombolytic candidates.
AB - An intensive early imaging approach using MR imaging before intra-arterial thrombolysis has provided considerable information regarding acute ischemic stroke, including the dynamic aspects of diffusion and perfusion abnormalities. Simple paradigms, such as diffusion-perfusion mismatch, have been transformed into refined models that estimate the extent of ischemic core and penumbra. MR imaging has also been advanced for the detection of intracranial hemorrhage, and may serve as the sole imaging modality before thrombolysis. Angiographic correlation at the time of thrombolysis has provided unique insight, delineating vascular correlates, including the degree of proximal arterial patency with recanalization and the extent of collateral flow. Although multivariate MR imaging models await prospective validation, these models may ultimately be used to optimize selection of ideal thrombolytic candidates.
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U2 - 10.1016/j.nic.2005.06.002
DO - 10.1016/j.nic.2005.06.002
M3 - Review article
C2 - 16198952
AN - SCOPUS:26044483545
SN - 1052-5149
VL - 15
SP - 455
EP - 466
JO - Neuroimaging Clinics of North America
JF - Neuroimaging Clinics of North America
IS - 2
ER -