Adrenal medulla denervation prevents stress-induced epinephrine plasma elevation and cardiac hypertrophy

J. R. Womble; D. F. Larson; J. G. Copeland; B. R. Brown; Mari K. Haddox; Diane Haddock Russell

doi:10.1016/0024-3205(80)90513-5

Adrenal medulla denervation prevents stress-induced epinephrine plasma elevation and cardiac hypertrophy

J. R. Womble, D. F. Larson, J. G. Copeland, B. R. Brown, Mari K. Haddox, Diane Haddock Russell

Surgery

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Circulating catecholamines have been proposed as trophic agents for the heart. Denervation of the adrenal medullae, the major source of plasma epinephrine, totally blocked left ventricular hypertrophy after aortic coarctation in the dog. The level of epinephrine after adrenal medullary cholinergic denervation dropped to a mean of 10 pg/ml within 48 hours compared to 317 pg/ml in coarcted dogs with intact adrenal innervation, and 116 pg/ml in sham-coarcted controls. Decreased epinephrine levels were concomitant with a decrease in the heart weight to body weight ratios. These data implicate epinephrine as the specific hormone regulating cardiac hypertrophy.

Original language	English (US)
Pages (from-to)	2417-2420
Number of pages	4
Journal	Life Sciences
Volume	27
Issue number	24
DOIs	https://doi.org/10.1016/0024-3205(80)90513-5
State	Published - Dec 15 1980

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/0024-3205(80)90513-5

Cite this

@article{3938369071e643f29ce09830f63b9347,

title = "Adrenal medulla denervation prevents stress-induced epinephrine plasma elevation and cardiac hypertrophy",

abstract = "Circulating catecholamines have been proposed as trophic agents for the heart. Denervation of the adrenal medullae, the major source of plasma epinephrine, totally blocked left ventricular hypertrophy after aortic coarctation in the dog. The level of epinephrine after adrenal medullary cholinergic denervation dropped to a mean of 10 pg/ml within 48 hours compared to 317 pg/ml in coarcted dogs with intact adrenal innervation, and 116 pg/ml in sham-coarcted controls. Decreased epinephrine levels were concomitant with a decrease in the heart weight to body weight ratios. These data implicate epinephrine as the specific hormone regulating cardiac hypertrophy.",

author = "Womble, {J. R.} and Larson, {D. F.} and Copeland, {J. G.} and Brown, {B. R.} and Haddox, {Mari K.} and {Haddock Russell}, Diane",

note = "Funding Information: This work was supported by Grant CA-14783 from the National Cancer Institute \[D.H.R.\]a nd by Grant HL-20984 from the National Heart and Lung Institute \[D.H.R.\],a nd by funds from Smith Kline and French Laboratories \[D.H.R.\]a nd from Eli Lilly and Company \[D.H.R., J.G.C.\].",

year = "1980",

month = dec,

day = "15",

doi = "10.1016/0024-3205(80)90513-5",

language = "English (US)",

volume = "27",

pages = "2417--2420",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "24",

}

TY - JOUR

T1 - Adrenal medulla denervation prevents stress-induced epinephrine plasma elevation and cardiac hypertrophy

AU - Womble, J. R.

AU - Larson, D. F.

AU - Copeland, J. G.

AU - Brown, B. R.

AU - Haddox, Mari K.

AU - Haddock Russell, Diane

N1 - Funding Information: This work was supported by Grant CA-14783 from the National Cancer Institute \[D.H.R.\]a nd by Grant HL-20984 from the National Heart and Lung Institute \[D.H.R.\],a nd by funds from Smith Kline and French Laboratories \[D.H.R.\]a nd from Eli Lilly and Company \[D.H.R., J.G.C.\].

PY - 1980/12/15

Y1 - 1980/12/15

N2 - Circulating catecholamines have been proposed as trophic agents for the heart. Denervation of the adrenal medullae, the major source of plasma epinephrine, totally blocked left ventricular hypertrophy after aortic coarctation in the dog. The level of epinephrine after adrenal medullary cholinergic denervation dropped to a mean of 10 pg/ml within 48 hours compared to 317 pg/ml in coarcted dogs with intact adrenal innervation, and 116 pg/ml in sham-coarcted controls. Decreased epinephrine levels were concomitant with a decrease in the heart weight to body weight ratios. These data implicate epinephrine as the specific hormone regulating cardiac hypertrophy.

AB - Circulating catecholamines have been proposed as trophic agents for the heart. Denervation of the adrenal medullae, the major source of plasma epinephrine, totally blocked left ventricular hypertrophy after aortic coarctation in the dog. The level of epinephrine after adrenal medullary cholinergic denervation dropped to a mean of 10 pg/ml within 48 hours compared to 317 pg/ml in coarcted dogs with intact adrenal innervation, and 116 pg/ml in sham-coarcted controls. Decreased epinephrine levels were concomitant with a decrease in the heart weight to body weight ratios. These data implicate epinephrine as the specific hormone regulating cardiac hypertrophy.

UR - http://www.scopus.com/inward/record.url?scp=0019196088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019196088&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(80)90513-5

DO - 10.1016/0024-3205(80)90513-5

M3 - Article

C2 - 6451781

AN - SCOPUS:0019196088

SN - 0024-3205

VL - 27

SP - 2417

EP - 2420

JO - Life Sciences

JF - Life Sciences

IS - 24

ER -

Adrenal medulla denervation prevents stress-induced epinephrine plasma elevation and cardiac hypertrophy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this