Administration of Exogenous Hormones and the Implications for Cigarette Smoking-Related Behaviors

Alicia Allen, Stephanie Mallahan, Alexis Ortega, Heather Miller, Ahlam Saleh, Andrea E. Bonny

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Purpose of Review: Preclinical evidence indicates progesterone and estrogen influence drug-taking behaviors, including nicotine/tobacco. However, clinical research on this relationship is less clear. This lack of clarity may be due to measuring naturally occurring endogenous hormones to examine this relationship, which introduces substantial error. Therefore, the goal of this review is to examine the link between the delivery of exogenous hormones and cigarette smoking-related behavior. Recent Findings: Exogenous progesterone may have favorable effects on cognition, symptomatology, consumption, and smoking cessation. Hormonal replacement therapy does not have a clear relationship with smoking-related behaviors. Oral contraceptive use may have adverse effects on stress response, nicotine metabolism, and symptomatology. Summary: Additional research is needed to explore how the administration of exogenous hormones may (a) strengthen research methodology on this topic, (b) enhance our understanding of the role of progesterone/estrogen on smoking-related behaviors, and (c) improve smoking cessation outcomes.

Original languageEnglish (US)
Article number70
JournalCurrent psychiatry reports
Issue number12
StatePublished - Dec 1 2020


  • Exogenous hormones
  • Hormonal contraceptives
  • Hormonal replacement therapy
  • Progesterone
  • Smoking behavior
  • Smoking cessation

ASJC Scopus subject areas

  • Psychiatry and Mental health


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