Adaptive Spinning-Disk Interferometry for Biomolecule Detection

Leilei Peng, Manoj M. Varma, David D. Nolte, H. Dorota Inerowicz, Fred E. Regnier

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We have identified a potential candidate for a high-throughput multi-analyte assay based on the optical compact disk (CD) in conjunction with adaptive homodyne detection using photorefractive quantum wells, and have succeeded in initial system tests that show our current ability to detect strips of immobilized molecules on a spinning disk of approximately 5 nm height. With the possibility of an improvement of nearly 100, this technique will be able to detect antibodies and antibody/antigen binding in immunological assays.

Original languageEnglish (US)
Title of host publicationPhotorefractive Effects, Materials, and Devices, PR 2003
PublisherOptica Publishing Group (formerly OSA)
Number of pages7
ISBN (Electronic)1557527555
StatePublished - 2003
Externally publishedYes
EventPhotorefractive Effects, Materials, and Devices, PR 2003 - La Colle sur Loup, France
Duration: Jun 17 2003 → …

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701


ConferencePhotorefractive Effects, Materials, and Devices, PR 2003
CityLa Colle sur Loup
Period6/17/03 → …

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials


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