Adaptive SPECT

Harrison H. Barrett, Lars R. Furenlid, Melanie Freed, Jacob Y. Hesterman, Matthew A. Kupinski, Eric Clarkson, Meredith K. Whitaker

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Adaptive imaging systems alter their data-acquisition configuration or protocol in response to the image information received. An adaptive pinhole single-photon emission computed tomography (SPECT) system might acquire an initial scout image to obtain preliminary information about the radiotracer distribution and then adjust the configuration or sizes of the pinholes, the magnifications, or the projection angles in order to improve performance. This paper briefly describes two small-animal SPECT systems that allow this flexibility and then presents a framework for evaluating adaptive systems in general, and adaptive SPECT systems in particular. The evaluation is in terms of the performance of linear observers on detection or estimation tasks. Expressions are derived for the ideal linear (Hotelling) observer and the ideal linear (Wiener) estimator with adaptive imaging. Detailed expressions for the performance figures of merit are given, and possible adaptation rules are discussed.

Original languageEnglish (US)
Article number4389806
Pages (from-to)775-788
Number of pages14
JournalIEEE Transactions on Medical Imaging
Issue number6
StatePublished - Jun 2008


  • Adaptive imaging
  • Hotelling observer
  • Image quality
  • Single-photon emission computed tomography (SPECT)
  • Wiener estimator

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering


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