Adaptive optical biocompact disk for molecular recognition

Leilei Peng, Manoj M. Varma, Fred E. Regnier, David D. Nolte

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


We report the use of adaptive interferometry to detect a monolayer of protein immobilized in a periodic pattern on a spinning glass disk. A photorefractive quantum-well device acting as an adaptive beam mixer in a two-wave mixing geometry stabilizes the interferometric quadrature in the far field. Phase modulation generated by the spinning biolayer pattern in the probe beam is detected as a homodyne signal free of amplitude modulation. Binding between antibodies and immobilized antigens in a two-analyte immunoassay was tested with high specificity and without observable cross reactivity.

Original languageEnglish (US)
Article number183902
Pages (from-to)1-3
Number of pages3
JournalApplied Physics Letters
Issue number18
StatePublished - May 2 2005

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)


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