Abstract
We report the use of adaptive interferometry to detect a monolayer of protein immobilized in a periodic pattern on a spinning glass disk. A photorefractive quantum-well device acting as an adaptive beam mixer in a two-wave mixing geometry stabilizes the interferometric quadrature in the far field. Phase modulation generated by the spinning biolayer pattern in the probe beam is detected as a homodyne signal free of amplitude modulation. Binding between antibodies and immobilized antigens in a two-analyte immunoassay was tested with high specificity and without observable cross reactivity.
Original language | English (US) |
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Article number | 183902 |
Pages (from-to) | 1-3 |
Number of pages | 3 |
Journal | Applied Physics Letters |
Volume | 86 |
Issue number | 18 |
DOIs | |
State | Published - May 2 2005 |
ASJC Scopus subject areas
- Physics and Astronomy (miscellaneous)