Acute lymphoblastic leukemia of the skin and subcutaneous tissues; the first manifestation of disease in a 6-month-old infant: A case report with literature review

Mihra S. Taljanovic; Rebecca L. Hulett; Anna R. Graham; Michael L. Graham; Tim B. Hunter

doi:10.1007/s10140-004-0368-x

Acute lymphoblastic leukemia of the skin and subcutaneous tissues; the first manifestation of disease in a 6-month-old infant: A case report with literature review

Mihra S. Taljanovic, Rebecca L. Hulett, Anna R. Graham, Michael L. Graham, Tim B. Hunter

Medical Imaging

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Leukemic infiltrate involving the skin and subcutaneous tissue was the first manifestation of disease in a 6-month-old female infant. Knowledge of age-related distribution patterns of the red (cellular) and yellow (fatty) marrow is crucial for the interpretation of magnetic resonance imaging (MRI) studies. Diffusely decreased signal intensity throughout the bone marrow on the T1-weighted images specifically involving the epiphyseal ossification centers in infants 6 months after their appearance should be suggestive of a marrow infiltrative/replacement process. Correlation with the peripheral blood smear and bone marrow aspirate are necessary for the diagnosis of leukemia.

Original language	English (US)
Pages (from-to)	60-64
Number of pages	5
Journal	Emergency Radiology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1007/s10140-004-0368-x
State	Published - Aug 2004

Keywords

Bone marrow MRI
Bone marrow infiltration
Leukemia skin

ASJC Scopus subject areas

Emergency Medicine
Radiology Nuclear Medicine and imaging

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10.1007/s10140-004-0368-x

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title = "Acute lymphoblastic leukemia of the skin and subcutaneous tissues; the first manifestation of disease in a 6-month-old infant: A case report with literature review",

abstract = "Leukemic infiltrate involving the skin and subcutaneous tissue was the first manifestation of disease in a 6-month-old female infant. Knowledge of age-related distribution patterns of the red (cellular) and yellow (fatty) marrow is crucial for the interpretation of magnetic resonance imaging (MRI) studies. Diffusely decreased signal intensity throughout the bone marrow on the T1-weighted images specifically involving the epiphyseal ossification centers in infants 6 months after their appearance should be suggestive of a marrow infiltrative/replacement process. Correlation with the peripheral blood smear and bone marrow aspirate are necessary for the diagnosis of leukemia.",

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AU - Hulett, Rebecca L.

AU - Graham, Anna R.

AU - Graham, Michael L.

AU - Hunter, Tim B.

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N2 - Leukemic infiltrate involving the skin and subcutaneous tissue was the first manifestation of disease in a 6-month-old female infant. Knowledge of age-related distribution patterns of the red (cellular) and yellow (fatty) marrow is crucial for the interpretation of magnetic resonance imaging (MRI) studies. Diffusely decreased signal intensity throughout the bone marrow on the T1-weighted images specifically involving the epiphyseal ossification centers in infants 6 months after their appearance should be suggestive of a marrow infiltrative/replacement process. Correlation with the peripheral blood smear and bone marrow aspirate are necessary for the diagnosis of leukemia.

AB - Leukemic infiltrate involving the skin and subcutaneous tissue was the first manifestation of disease in a 6-month-old female infant. Knowledge of age-related distribution patterns of the red (cellular) and yellow (fatty) marrow is crucial for the interpretation of magnetic resonance imaging (MRI) studies. Diffusely decreased signal intensity throughout the bone marrow on the T1-weighted images specifically involving the epiphyseal ossification centers in infants 6 months after their appearance should be suggestive of a marrow infiltrative/replacement process. Correlation with the peripheral blood smear and bone marrow aspirate are necessary for the diagnosis of leukemia.

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KW - Leukemia skin

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Acute lymphoblastic leukemia of the skin and subcutaneous tissues; the first manifestation of disease in a 6-month-old infant: A case report with literature review

Abstract

Keywords

ASJC Scopus subject areas

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