Acute lower respiratory illnesses during the first three years of life: Potential roles for various etiologic agents

The group health medical associates

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47 Scopus citations


Lower respiratory tract illnesses (LRIs) occurring during the first 3 years of life among children enrolled in the Tucson Children’s Respiratory Study have been studied for evidence of viral, mycoplasmal and Chlamydia trachomatis infections. This report examines those from whom adequate acute and convalescent sera were available at the time of the LRI. Two groups were compared: those in whom culture and/or antigen detection yielded an etiologic agent (N = 110); and those who did not (culture negative, N = 124). Seroconversions (≥ fold titer rise) to respiratory syncytial virus; influenza virus types A and B; parainfluenza virus types 1, 2 and 3; or adenovirus were found in only 0 to 5% of the culture negative group. No significant differences between groups with regard to frequencies of seroconversion to influenza type C, parainfluenza virus type 4, human coronaviruses 229E and OC43 or cytomegalovirus were detected, which suggests that these agents may not be frequent primary causes of LRIs among otherwise healthy children. Significant differences in sero conversions to Epstein Barr virus were detected, suggesting that Epstein-Barr virus may contribute to LRI morbidity; however, its exact role remains to be defined.

Original languageEnglish (US)
Pages (from-to)10-14
Number of pages5
JournalPediatric Infectious Disease Journal
Issue number1
StatePublished - Jan 1993


  • Adenoviruses
  • Coronaviruses
  • Cytomegalovirus
  • Epstein-barr virus
  • Influenza virus
  • Lower respiratory tract infections
  • Parainfluenza viruses
  • Res-piratory syncytial virus
  • Respiratory viruses

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases


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