TY - JOUR
T1 - Acute bronchodilating effects of ipratropium bromide and theophylline in chronic obstructive pulmonary disease
AU - Bleecker, Eugene R.
AU - Britt, E. James
N1 - Funding Information:
From the Division of Pulmonary and Critical Care Medicine, University of Mary land School of Medlclne, and Francis Scott Key Medical Center, Baltimore, Maryland. This research was funded by a grant from Boehrlnger lngelheim Pharmaceuticals, Inc., Ridgefield, Connecticut. Requests fo; reprints should be addressed to Eugene R. Bleecker, M.D., Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, MSTF Room 800, 10 South Pine Street, Baltimore, Maryland 21201.
PY - 1991/10/21
Y1 - 1991/10/21
N2 - The bronchodilator effects of a single dose of ipratropium bromide aerosol (36 μg) and short-acting theophylline tablets (dose titrated to produce serum levels of 10-20 μg/mL) were compared in a double-blind, placebo-controlled crossover study in 21 patients with stable, chronic obstructive pulmonary disease. Mean peak forced expiratory volume in 1 second (FEV1) increases over baseline and the proportion of patients attaining at least a 15% increase in the FEV1 (responders) were 31% and 90%, respectively, for ipratropium and 17% and 50%, respectively, for theophylline. The average FEV1 increases during the 6-hour observation period were 18% for ipratropium and 8% for theophylline. The mean duration of action was 3.8 hours with ipratropium and 2.4 hours with theophylline. While side effects were rare, those experienced after theophylline use did involve the cardiovascular and gastrointestinal systems. These results show that ipratropium is a more potent bronchodilator than oral theophylline in patients with chronic airflow obstruction.
AB - The bronchodilator effects of a single dose of ipratropium bromide aerosol (36 μg) and short-acting theophylline tablets (dose titrated to produce serum levels of 10-20 μg/mL) were compared in a double-blind, placebo-controlled crossover study in 21 patients with stable, chronic obstructive pulmonary disease. Mean peak forced expiratory volume in 1 second (FEV1) increases over baseline and the proportion of patients attaining at least a 15% increase in the FEV1 (responders) were 31% and 90%, respectively, for ipratropium and 17% and 50%, respectively, for theophylline. The average FEV1 increases during the 6-hour observation period were 18% for ipratropium and 8% for theophylline. The mean duration of action was 3.8 hours with ipratropium and 2.4 hours with theophylline. While side effects were rare, those experienced after theophylline use did involve the cardiovascular and gastrointestinal systems. These results show that ipratropium is a more potent bronchodilator than oral theophylline in patients with chronic airflow obstruction.
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U2 - 10.1016/0002-9343(91)90258-Y
DO - 10.1016/0002-9343(91)90258-Y
M3 - Article
C2 - 1835291
AN - SCOPUS:44949272227
SN - 0002-9343
VL - 91
SP - S24-S27
JO - The American journal of medicine
JF - The American journal of medicine
IS - 4 SUPPL. 1
ER -