Activity of parthenolide at 5HT(2A) receptors

John T. Weber; Mary Frances O'Connor; Kenneth Hayataka; Nancy Colson; Rustem Medora; Ethan B. Russo; Keith K. Parker

doi:10.1021/np960644d

Activity of parthenolide at 5HT(2A) receptors

John T. Weber, Mary Frances O'Connor, Kenneth Hayataka, Nancy Colson, Rustem Medora, Ethan B. Russo, Keith K. Parker

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Parthenolide displaces [³H]ketanserin from 5HT(2A) receptors from rat and rabbit brain and cloned 5HT(2A) receptors. K(i)'s are in the 100-250 μM range. These results suggest that parthenolide may be a low-affinity antagonist at 5HT receptors; it is unlikely that the entire mechanism of action can be explained by its modest 5HT(2A) receptor affinity.

Original language	English (US)
Pages (from-to)	651-653
Number of pages	3
Journal	Journal Of Natural Products
Volume	60
Issue number	6
DOIs	https://doi.org/10.1021/np960644d
State	Published - Jun 1997
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np960644d

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abstract = "Parthenolide displaces [3H]ketanserin from 5HT(2A) receptors from rat and rabbit brain and cloned 5HT(2A) receptors. K(i)'s are in the 100-250 μM range. These results suggest that parthenolide may be a low-affinity antagonist at 5HT receptors; it is unlikely that the entire mechanism of action can be explained by its modest 5HT(2A) receptor affinity.",

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AU - O'Connor, Mary Frances

AU - Hayataka, Kenneth

AU - Colson, Nancy

AU - Medora, Rustem

AU - Russo, Ethan B.

AU - Parker, Keith K.

PY - 1997/6

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AB - Parthenolide displaces [3H]ketanserin from 5HT(2A) receptors from rat and rabbit brain and cloned 5HT(2A) receptors. K(i)'s are in the 100-250 μM range. These results suggest that parthenolide may be a low-affinity antagonist at 5HT receptors; it is unlikely that the entire mechanism of action can be explained by its modest 5HT(2A) receptor affinity.

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Activity of parthenolide at 5HT(2A) receptors

Abstract

ASJC Scopus subject areas

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