TY - JOUR
T1 - Acrylamide
T2 - Dermal exposure produces genetic damage in male mouse germ cells
AU - Gutierrez-espeleta, Gustavo A.
AU - Hughes, Lori A.
AU - Piegorsch, Walter W.
AU - Shelby, Michael D.
AU - Generoso, Walderico M.
N1 - Funding Information:
Research was jointly sponsored by the Office of Health and Environmental Research, U.S. Department of Energy, under contract DE-ACO5-840R21400 with Martin Marietta Energy Systems, Inc., and by the National Institute of Environmental Health Sciences under IAG YOl-ES-20085. We thank Dr. Jack B. Bishop, Dr. Mary Esther Gaulden, Dr. Joseph K. Haseman, Dr. Jerrold S. Heindel. and Dr. Gary A. Sega for their critical review of the manuscript.
PY - 1992/2
Y1 - 1992/2
N2 - Acrylamide is used extensively in sewage and wastewater treatment plants, in the paper and pulp industry, in treatment of potable water, and in research laboratories for chromatography, electrophoresis, and electron microscopy. Dermal contact is a major route of human exposure. It has been shown that acrylamide is highly effective in breaking chromosomes of germ cells of male mice and rats when administered intraperitoneally or orally, resulting both in the early death of conceptuses and in the transmission of reciprocal translocations to live-born progeny. It is now reported that acrylamide is absorbed through the skin of male mice, reaches the germ cells, and induces chromosomal damage. The magnitude of genetic damage appears to be proportional to the dose administered topically.
AB - Acrylamide is used extensively in sewage and wastewater treatment plants, in the paper and pulp industry, in treatment of potable water, and in research laboratories for chromatography, electrophoresis, and electron microscopy. Dermal contact is a major route of human exposure. It has been shown that acrylamide is highly effective in breaking chromosomes of germ cells of male mice and rats when administered intraperitoneally or orally, resulting both in the early death of conceptuses and in the transmission of reciprocal translocations to live-born progeny. It is now reported that acrylamide is absorbed through the skin of male mice, reaches the germ cells, and induces chromosomal damage. The magnitude of genetic damage appears to be proportional to the dose administered topically.
UR - https://www.scopus.com/pages/publications/77957186638
UR - https://www.scopus.com/pages/publications/77957186638#tab=citedBy
U2 - 10.1016/0272-0590(92)90045-j
DO - 10.1016/0272-0590(92)90045-j
M3 - Article
C2 - 1601219
AN - SCOPUS:77957186638
SN - 1096-6080
VL - 18
SP - 189
EP - 192
JO - Toxicological Sciences
JF - Toxicological Sciences
IS - 2
ER -