Acridone alkaloids and coumarins from Pleiospermium alatum

B. M.Ratnayake Bandara, A. A.Leslie Gunatilaka, E. M.Kithsiri Wijeratne, John K. MacLeod

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


The root bark of Pleiospermium alatum afforded five alkaloids, five coumarins, lupeol and stigmasterol. One of the acridones, 1,5,6-trihydroxy-2,3-dimethoxy-10-methyl-9-acridone is a new compound while another, 1-hydroxy-2,3,5,6-tetramethoxy-10-methyl-9-acridone, is a new natural product. Chemotaxonomic aspects of the occurrence of acridone and coumarins in Pleiospermium is discussed. Seselin, one of the coumarins encountered displayed significant antifungal activity against Cladosporium cladosporioides.

Original languageEnglish (US)
Pages (from-to)297-301
Number of pages5
Issue number1
StatePublished - 1990


  • Pleiospermium alatum
  • Rutaceae
  • acridone alkaloids
  • antifungal activity.
  • chemotaxonomy
  • coumarins
  • lupeol
  • stigmasterol

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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