TY - JOUR
T1 - Acoustoelectric Time-Reversal for Ultrasound Phase-Aberration Correction
AU - Preston, Chet
AU - Alvarez, Alexander M.
AU - Allard, Margaret
AU - Barragan, Andres
AU - Witte, Russell S.
N1 - Funding Information:
Date of publication 5 July 2023; date of current version 2 August 2023. This work was supported in part by the National Institute of Health under Grant U01EB028662, Grant U01EB029834, Grant T32GM132008, Grant T32EB000809, and Grant R25HD080811.
Publisher Copyright:
© 1986-2012 IEEE.
PY - 2023/8/1
Y1 - 2023/8/1
N2 - Acoustoelectric imaging (AEI) is a technique that combines ultrasound (US) with radio frequency recording to detect and map local current source densities. This study demonstrates a new method called acoustoelectric time reversal (AETR), which uses AEI of a small current source to correct for phase aberrations through a skull or other US-aberrating layers with applications to brain imaging and therapy. Simulations conducted at three different US frequencies (0.5, 1.5, and 2.5 MHz) were performed through media layered with different sound speeds and geometries to induce aberrations of the US beam. Time delays of the acoustoelectric (AE) signal from a monopole within the medium were calculated for each element to enable corrections using AETR. Uncorrected aberrated beam profiles were compared with those after applying AETR corrections, which demonstrated a strong recovery (29%-100%) of lateral resolution and increases in focal pressure up to 283%. To further demonstrate the practical feasibility of AETR, we further conducted bench-top experiments using a 2.5 MHz linear US array to perform AETR through 3-D-printed aberrating objects. These experiments restored lost lateral restoration up to 100% for the different aberrators and increased focal pressure up to 230% after applying AETR corrections. Cumulatively, these results highlight AETR as a powerful tool for correcting focal aberrations in the presence of a local current source with applications to AEI, US imaging, neuromodulation, and therapy.
AB - Acoustoelectric imaging (AEI) is a technique that combines ultrasound (US) with radio frequency recording to detect and map local current source densities. This study demonstrates a new method called acoustoelectric time reversal (AETR), which uses AEI of a small current source to correct for phase aberrations through a skull or other US-aberrating layers with applications to brain imaging and therapy. Simulations conducted at three different US frequencies (0.5, 1.5, and 2.5 MHz) were performed through media layered with different sound speeds and geometries to induce aberrations of the US beam. Time delays of the acoustoelectric (AE) signal from a monopole within the medium were calculated for each element to enable corrections using AETR. Uncorrected aberrated beam profiles were compared with those after applying AETR corrections, which demonstrated a strong recovery (29%-100%) of lateral resolution and increases in focal pressure up to 283%. To further demonstrate the practical feasibility of AETR, we further conducted bench-top experiments using a 2.5 MHz linear US array to perform AETR through 3-D-printed aberrating objects. These experiments restored lost lateral restoration up to 100% for the different aberrators and increased focal pressure up to 230% after applying AETR corrections. Cumulatively, these results highlight AETR as a powerful tool for correcting focal aberrations in the presence of a local current source with applications to AEI, US imaging, neuromodulation, and therapy.
KW - High intensity focused ultrasound ablation (HIFU)
KW - skull aberrations
KW - time reversal (TR)
KW - transcranial brain imaging
KW - ultrasound (US) neuromodulation
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U2 - 10.1109/TUFFC.2023.3292595
DO - 10.1109/TUFFC.2023.3292595
M3 - Article
C2 - 37405897
AN - SCOPUS:85164442568
SN - 0885-3010
VL - 70
SP - 854
EP - 864
JO - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
JF - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
IS - 8
ER -