TY - GEN
T1 - Acoustoelectric imaging of time-varying current produced by a clinical deep brain stimulator
AU - Preston, Chet
AU - Qin, Yexian
AU - Ingram, Pier
AU - Kassof, Willard
AU - Burton, Alex
AU - Witte, Russell S.
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2017/10/31
Y1 - 2017/10/31
N2 - Deep brain stimulation (DBS) is an effective treatment for a variety of brain disorders, including Parkinson's disease, depression and chronic pain. However, there is no reliable method to non-invasively image electric current flow generated by a DBS. In this study, we demonstrate 4D current source density imaging based on the acoustoelectric (AE) effect, which integrates an ultrasound beam with electrical recording, to map current flow produced by a clinical DBS device. AE imaging was able to accurately determine the polarity, magnitude and location of the current densities near the DBS device placed in physiologic saline with a signal-to-noise ratio of 17.1 dB using stimulation parameters similar to what are used on patients. Pulse echo (PE) ultrasound was acquired simultaneously to provide additional information regarding the spatial coordinates and structure of the DBS without need of additional techniques. These results suggest that AE imaging combined with PE ultrasound may provide valuable feedback during and after implantation of a DBS device.
AB - Deep brain stimulation (DBS) is an effective treatment for a variety of brain disorders, including Parkinson's disease, depression and chronic pain. However, there is no reliable method to non-invasively image electric current flow generated by a DBS. In this study, we demonstrate 4D current source density imaging based on the acoustoelectric (AE) effect, which integrates an ultrasound beam with electrical recording, to map current flow produced by a clinical DBS device. AE imaging was able to accurately determine the polarity, magnitude and location of the current densities near the DBS device placed in physiologic saline with a signal-to-noise ratio of 17.1 dB using stimulation parameters similar to what are used on patients. Pulse echo (PE) ultrasound was acquired simultaneously to provide additional information regarding the spatial coordinates and structure of the DBS without need of additional techniques. These results suggest that AE imaging combined with PE ultrasound may provide valuable feedback during and after implantation of a DBS device.
KW - Brain Implant Current Source Densities
KW - Elecrical Brain Mapping
KW - Electrical Impedance Imaging
KW - Parkinson's Disease
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85039434874&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85039434874&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2017.8092832
DO - 10.1109/ULTSYM.2017.8092832
M3 - Conference contribution
AN - SCOPUS:85039434874
T3 - IEEE International Ultrasonics Symposium, IUS
BT - 2017 IEEE International Ultrasonics Symposium, IUS 2017
PB - IEEE Computer Society
T2 - 2017 IEEE International Ultrasonics Symposium, IUS 2017
Y2 - 6 September 2017 through 9 September 2017
ER -