Acoustic response of phase change contrast agents targeted with breast cancer cells immediately after ultrasonic activation using ultrafast imaging

Ge Zhang; Shengtao Lin; Chee Hau Leow; Kuin Pang; Javier Hernandez Gil; Terry Matsunaga; Mengxing Tang

doi:10.1109/ULTSYM.2017.8091642

Acoustic response of phase change contrast agents targeted with breast cancer cells immediately after ultrasonic activation using ultrafast imaging

Ge Zhang
, Shengtao Lin
, Chee Hau Leow
, Kuin Pang
, Javier Hernandez Gil
, Terry Matsunaga
, Mengxing Tang

Neurosurgery

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Phase-change contrast agents (PCCAs) have advantageous properties in terms of smaller size, longer half-life and selective activation control compared to conventional microbubble contrast agents (MCAs), which make them ideal for ultrasound cancer imaging. [1] Acoustic signal from tumour site can be further enhanced by receptor targeted PCCAs. However there is still a lack of understanding of the behaviour of these targeted agents. In this work, we report the use of high frame rate (HFR) imaging to investigate the changes in acoustic signal of Folate Receptor (FR)-targeted versus control PCCAs with breast cancer cells immediately after acoustic activation.

Original language	English (US)
Title of host publication	2017 IEEE International Ultrasonics Symposium, IUS 2017
Publisher	IEEE Computer Society
ISBN (Electronic)	9781538633830
DOIs	https://doi.org/10.1109/ULTSYM.2017.8091642
State	Published - Oct 31 2017
Event	2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States Duration: Sep 6 2017 → Sep 9 2017

Publication series

Name	IEEE International Ultrasonics Symposium, IUS
ISSN (Print)	1948-5719
ISSN (Electronic)	1948-5727

Other

Other	2017 IEEE International Ultrasonics Symposium, IUS 2017
Country/Territory	United States
City	Washington
Period	9/6/17 → 9/9/17

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2017.8091642

Cite this

Zhang, G., Lin, S., Leow, C. H., Pang, K., Gil, J. H., Matsunaga, T., & Tang, M. (2017). Acoustic response of phase change contrast agents targeted with breast cancer cells immediately after ultrasonic activation using ultrafast imaging. In 2017 IEEE International Ultrasonics Symposium, IUS 2017 Article 8091642 (IEEE International Ultrasonics Symposium, IUS). IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2017.8091642

Acoustic response of phase change contrast agents targeted with breast cancer cells immediately after ultrasonic activation using ultrafast imaging. / Zhang, Ge; Lin, Shengtao; Leow, Chee Hau et al.
2017 IEEE International Ultrasonics Symposium, IUS 2017. IEEE Computer Society, 2017. 8091642 (IEEE International Ultrasonics Symposium, IUS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Zhang, G, Lin, S, Leow, CH, Pang, K, Gil, JH, Matsunaga, T & Tang, M 2017, Acoustic response of phase change contrast agents targeted with breast cancer cells immediately after ultrasonic activation using ultrafast imaging. in 2017 IEEE International Ultrasonics Symposium, IUS 2017., 8091642, IEEE International Ultrasonics Symposium, IUS, IEEE Computer Society, 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States, 9/6/17. https://doi.org/10.1109/ULTSYM.2017.8091642

Zhang G, Lin S, Leow CH, Pang K, Gil JH, Matsunaga T et al. Acoustic response of phase change contrast agents targeted with breast cancer cells immediately after ultrasonic activation using ultrafast imaging. In 2017 IEEE International Ultrasonics Symposium, IUS 2017. IEEE Computer Society. 2017. 8091642. (IEEE International Ultrasonics Symposium, IUS). doi: 10.1109/ULTSYM.2017.8091642

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title = "Acoustic response of phase change contrast agents targeted with breast cancer cells immediately after ultrasonic activation using ultrafast imaging",

abstract = "Phase-change contrast agents (PCCAs) have advantageous properties in terms of smaller size, longer half-life and selective activation control compared to conventional microbubble contrast agents (MCAs), which make them ideal for ultrasound cancer imaging. [1] Acoustic signal from tumour site can be further enhanced by receptor targeted PCCAs. However there is still a lack of understanding of the behaviour of these targeted agents. In this work, we report the use of high frame rate (HFR) imaging to investigate the changes in acoustic signal of Folate Receptor (FR)-targeted versus control PCCAs with breast cancer cells immediately after acoustic activation.",

author = "Ge Zhang and Shengtao Lin and Leow, \{Chee Hau\} and Kuin Pang and Gil, \{Javier Hernandez\} and Terry Matsunaga and Mengxing Tang",

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doi = "10.1109/ULTSYM.2017.8091642",

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AB - Phase-change contrast agents (PCCAs) have advantageous properties in terms of smaller size, longer half-life and selective activation control compared to conventional microbubble contrast agents (MCAs), which make them ideal for ultrasound cancer imaging. [1] Acoustic signal from tumour site can be further enhanced by receptor targeted PCCAs. However there is still a lack of understanding of the behaviour of these targeted agents. In this work, we report the use of high frame rate (HFR) imaging to investigate the changes in acoustic signal of Folate Receptor (FR)-targeted versus control PCCAs with breast cancer cells immediately after acoustic activation.

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Acoustic response of phase change contrast agents targeted with breast cancer cells immediately after ultrasonic activation using ultrafast imaging

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