@article{a1772662b0c34abd8927bf198dd51310,
title = "Acid-Promoted One-Pot Synthesis of Substituted Furan and 6-Methylpyrazin-2(1 H)-one Derivatives via Allene Intermediate Formed in Situ",
abstract = "Under the acidic conditions, substituted furans were constructed from γ-alkynyl ketones through corresponding allene intermediates in one-pot. The methodology was also tailored to a series of the Ugi reaction products for the synthesis of 6-methylpyrazin-2(1H)-one derivatives. The current method offered significant advantages for the combinatorial applications of these chemical scaffolds.",
keywords = "6-methylpyrazin-2(1 H)-one, Ugi reaction, allene, multicomponent reaction (MCR), substituted furans",
author = "Jie Lei and Xu, {Zhi Gang} and Tang, {Dian Yong} and Yong Li and Jia Xu and Li, {Hong Yu} and Jin Zhu and Chen, {Zhong Zhu}",
note = "Funding Information: *E-mail: jinzhu@cioc.ac.cn. *E-mail: 188837138277@163.com. ORCID Zhi-Gang Xu: 0000-0003-0190-1313 Dian-Yong Tang: 0000-0001-9389-870X Author Contributions The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript. Funding This work was supported by the Chongqing Research Program of Basic Research and Frontier Technology (cstc2015jcy-jA1328, cstc2015zdcy-ztzx120003, and cstc2015zdcy-ztzx0191), Chongqing Education commission Project of China (KJZH17129), and the Scientific Research Foundation of Chongqing University of Arts and Sciences (Grant Nos. R2013XY01 and R2013XY02). H.L. was supported by the grants (NIH 1R01CA194094-010 and 1R01CA197178-01A1). Notes The authors declare no competing financial interest. Funding Information: †Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China ‡University of Chinese Academy of Sciences, Beijing 100049, China #Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI, Chongqing University of Arts and Sciences, 319 Honghe Avenue, Yongchuan, Chongqing, 402160, China ∥Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = may,
day = "14",
doi = "10.1021/acscombsci.8b00005",
language = "English (US)",
volume = "20",
pages = "292--297",
journal = "ACS Combinatorial Science",
issn = "2156-8952",
publisher = "American Chemical Society",
number = "5",
}