@article{6892ef27faf14a1a88fe53f4049c24a9,
title = "Acetyl cyanide as a cyanide source in a tandem catalyst-free modified Groebke-Blackburn-Bienaym{\'e} [4+1]-cycloaddition-Strecker cascade",
abstract = "A concise one-pot 3-step cascade reaction to biologically significant imidazo[1,2-a]heterocycles is described. The methodology utilizes acetyl cyanide as a non-classical isocyanide replacement for TMSCN in a microwave-assisted [4+1] cycloaddition (the Groebke-Bienaym{\'e}-Blackburn reaction) followed by a Strecker reaction under catalysis free conditions. The methodology proceeds with operational simplicity, short reaction times, and high bond forming efficiency.",
keywords = "Bicyclic heterocycles, Groebke-Blackburn-Bienaym{\'e}, Imidazopyridine, Multicomponent reaction, Strecker",
author = "Guillermo Martinez-Ariza and Jose Nunez-Rios and Lee, {Yeon Sun} and Christopher Hulme",
note = "Funding Information: The authors acknowledge financial support from a CONACyT/UA (doctoral fellowship 215981/311412 for G.M.A.), and the 100,000 strong in the Americas scholarship to attend the 2014 Latin America Summer Research Program (J.N.R.). We also thank the organizers of this program at the UA (Dr. Maria Teresa Velez and Dr. Nadia Alvarez-Mexia) and Universidad de Guanajuato (Dr. Sergio Arias-Negrete). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",
year = "2015",
month = feb,
day = "18",
doi = "10.1016/j.tetlet.2014.12.127",
language = "English (US)",
volume = "56",
pages = "1038--1040",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "8",
}