TY - JOUR
T1 - Acetaminophen Poisoning in Infancy
AU - Greene, John W.
AU - Craft, Lisa
AU - Ghishan, Fayez
PY - 1983/4
Y1 - 1983/4
N2 - Acetaminophen is widely used in children of all ages, and overdosage from this medication is common. Although severe hepatotoxicity from overdosage occurs in adults, acetaminophen seems to have a wide margin of safety in younger children. This has been ascribed to altered pharmacokinetics in this age group. We report two cases in which severe acetaminopheninduced hepatotoxicity occurred in two infants. Neither infant reportedly received potentially toxic dosages, by history, but toxic drug levels were present in both.
AB - Acetaminophen is widely used in children of all ages, and overdosage from this medication is common. Although severe hepatotoxicity from overdosage occurs in adults, acetaminophen seems to have a wide margin of safety in younger children. This has been ascribed to altered pharmacokinetics in this age group. We report two cases in which severe acetaminopheninduced hepatotoxicity occurred in two infants. Neither infant reportedly received potentially toxic dosages, by history, but toxic drug levels were present in both.
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U2 - 10.1001/archpedi.1983.02140300064018
DO - 10.1001/archpedi.1983.02140300064018
M3 - Article
C2 - 6829518
AN - SCOPUS:0020678151
VL - 137
SP - 386
EP - 387
JO - A.M.A. American journal of diseases of children
JF - A.M.A. American journal of diseases of children
SN - 2168-6203
IS - 4
ER -