Accuracy of CT biopsy: Laser guidance versus conventional freehand techniques

F. S. Pereles, M. Baker, R. Baldwin, E. Krupinski, E. C. Unger

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Rationale and Objectives. The purpose of this study was to determine whether laser-guided computed tomographic (CT) biopsy is more accurate that cT-guided biopsy with conventional freehand techniques. Materials and Methods. Two independent operators performed an equal number of freehand and laser-guided needle passes at varying single and double angles (0°, 30°, 60°, 25°/30°, and 25°/60°) on targets within six pork and beef phantoms. A total of 180 biopsy passes were performed, and errors distances of needle tip to target were tabulated. Data were analyzed by means of repeated measures analysis of variance (ANOVA) to compare the accuracy of laser guidance with freehand passes. ANOVA and correlation analysis were also used to confirm the relative equivalency of phantom targets and biopsy parameters. Results. Overall, laser-guided passes were statistically significantly more accurate than freehand passes. Mean error with laser guidance was 5.01 mm (standard error [SE] = 0.41 mm), whereas mean error with freehand techniques was 10.58 mm (SE = 0.82 mm) (F = 52.0, df = 1.17, P = .0001). Ninety-three percent of laser-guided passes and 56% of freehand passes were within 1 cm of the intended target. Error increased for both laser-guided and freehand techniques with larger angles or double-angle biopsies, but the increases were greater with free hand technique. No statistically significant differences existed between the targets themselves or biopsy parameters for the two operators. Conclusion. Laser-guided CT biopsies were more accurate than freehand CT biopsies. Practical advantages of laser guidance over freehand CT biopsy methods may include decreased procedure times and reduced patient morbidity.

Original languageEnglish (US)
Pages (from-to)766-770
Number of pages5
JournalAcademic radiology
Issue number11 SUPPL. 3
StatePublished - 1998


  • Biopsies, technology
  • Computed tomography (CT), guidance
  • Lasers

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Accuracy of CT biopsy: Laser guidance versus conventional freehand techniques'. Together they form a unique fingerprint.

Cite this