Accumulation of myosin, actin, tropomyosin, and α-actinin in cultured muscle cells

Ronald E. Allen; Marvin H. Stromer; Darrel E. Goll; Richard M. Robson

doi:10.1016/0012-1606(79)90318-X

Accumulation of myosin, actin, tropomyosin, and α-actinin in cultured muscle cells

Ronald E. Allen
, Marvin H. Stromer
, Darrel E. Goll
, Richard M. Robson

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

In an effort to understand the conditions that promote the assembly of myofibrillar proteins in muscle cells, the temporal sequence of accumulation of four myofibrillar proteins, actin, myosin, tropomyosin, and α-actinin, was monitored during the period of de novo assembly of myofibrils in differentiating muscle cells. Isotope dilution experiments indicated that all four proteins were accumulated simultaneously. Therefore, assembly of myofibrils may be occurring in the presence of a full complement of myofibrillar proteins.

Original language	English (US)
Pages (from-to)	655-660
Number of pages	6
Journal	Developmental biology
Volume	69
Issue number	2
DOIs	https://doi.org/10.1016/0012-1606(79)90318-X
State	Published - Apr 1979

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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10.1016/0012-1606(79)90318-X

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@article{edd699ebc3f248ca9c622b5326e361df,

title = "Accumulation of myosin, actin, tropomyosin, and α-actinin in cultured muscle cells",

abstract = "In an effort to understand the conditions that promote the assembly of myofibrillar proteins in muscle cells, the temporal sequence of accumulation of four myofibrillar proteins, actin, myosin, tropomyosin, and α-actinin, was monitored during the period of de novo assembly of myofibrils in differentiating muscle cells. Isotope dilution experiments indicated that all four proteins were accumulated simultaneously. Therefore, assembly of myofibrils may be occurring in the presence of a full complement of myofibrillar proteins.",

author = "Allen, \{Ronald E.\} and Stromer, \{Marvin H.\} and Goll, \{Darrel E.\} and Robson, \{Richard M.\}",

note = "Funding Information: {\textquoteright} Michigan Agricultural Experiment Station Article No. 8663. This work was supported by Michigan Agricultural Experiment Station Projects 1280 and 1182 and by a Biomedical Research Support Grant from the College of Agriculture and Natural Resources. Iowa Agriculture and Home Economics Experiment Station journal paper No. J-9010, Projects 2025 and 2127. This work was also supported in part by Grants HL-15679 and AM-12654 from the National Institutes of Health and by grants from the Muscular Dystrophy Associations of America and the Iowa Heart Association.",

year = "1979",

month = apr,

doi = "10.1016/0012-1606(79)90318-X",

language = "English (US)",

volume = "69",

pages = "655--660",

journal = "Developmental biology",

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AU - Allen, Ronald E.

AU - Stromer, Marvin H.

AU - Goll, Darrel E.

AU - Robson, Richard M.

N1 - Funding Information: ’ Michigan Agricultural Experiment Station Article No. 8663. This work was supported by Michigan Agricultural Experiment Station Projects 1280 and 1182 and by a Biomedical Research Support Grant from the College of Agriculture and Natural Resources. Iowa Agriculture and Home Economics Experiment Station journal paper No. J-9010, Projects 2025 and 2127. This work was also supported in part by Grants HL-15679 and AM-12654 from the National Institutes of Health and by grants from the Muscular Dystrophy Associations of America and the Iowa Heart Association.

PY - 1979/4

Y1 - 1979/4

N2 - In an effort to understand the conditions that promote the assembly of myofibrillar proteins in muscle cells, the temporal sequence of accumulation of four myofibrillar proteins, actin, myosin, tropomyosin, and α-actinin, was monitored during the period of de novo assembly of myofibrils in differentiating muscle cells. Isotope dilution experiments indicated that all four proteins were accumulated simultaneously. Therefore, assembly of myofibrils may be occurring in the presence of a full complement of myofibrillar proteins.

AB - In an effort to understand the conditions that promote the assembly of myofibrillar proteins in muscle cells, the temporal sequence of accumulation of four myofibrillar proteins, actin, myosin, tropomyosin, and α-actinin, was monitored during the period of de novo assembly of myofibrils in differentiating muscle cells. Isotope dilution experiments indicated that all four proteins were accumulated simultaneously. Therefore, assembly of myofibrils may be occurring in the presence of a full complement of myofibrillar proteins.

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U2 - 10.1016/0012-1606(79)90318-X

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ER -

Accumulation of myosin, actin, tropomyosin, and α-actinin in cultured muscle cells

Abstract

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