Accumulation of myosin, actin, tropomyosin, and α-actinin in cultured muscle cells

Ronald E. Allen, Marvin H. Stromer, Darrel E. Goll, Richard M. Robson

    Research output: Contribution to journalArticlepeer-review

    9 Scopus citations

    Abstract

    In an effort to understand the conditions that promote the assembly of myofibrillar proteins in muscle cells, the temporal sequence of accumulation of four myofibrillar proteins, actin, myosin, tropomyosin, and α-actinin, was monitored during the period of de novo assembly of myofibrils in differentiating muscle cells. Isotope dilution experiments indicated that all four proteins were accumulated simultaneously. Therefore, assembly of myofibrils may be occurring in the presence of a full complement of myofibrillar proteins.

    Original languageEnglish (US)
    Pages (from-to)655-660
    Number of pages6
    JournalDevelopmental biology
    Volume69
    Issue number2
    DOIs
    StatePublished - Apr 1979

    ASJC Scopus subject areas

    • Molecular Biology
    • Developmental Biology
    • Cell Biology

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