TY - JOUR
T1 - Accommodation
T2 - Preventing Injury in Transplantation and Disease
AU - Koch, Cody A.
AU - Khalpey, Zain I.
AU - Platt, Jeffrey L.
PY - 2004/5/1
Y1 - 2004/5/1
N2 - Humoral immunity, as a cause of damage to blood vessels, poses a major barrier to successful transplantation of organs. Under some conditions, humoral immunity causes little or no damage to an organ graft. We have referred to this condition, in which a vascularized graft functions in the face of humoral immunity directed against it, as "accommodation." In this paper, we review changes in the graft and in the host that may account for accommodation, and we consider that what we call accommodation of organ grafts may occur widely in the context of immune responses, enabling immune responses to target infectious organisms without harming self-tissues.
AB - Humoral immunity, as a cause of damage to blood vessels, poses a major barrier to successful transplantation of organs. Under some conditions, humoral immunity causes little or no damage to an organ graft. We have referred to this condition, in which a vascularized graft functions in the face of humoral immunity directed against it, as "accommodation." In this paper, we review changes in the graft and in the host that may account for accommodation, and we consider that what we call accommodation of organ grafts may occur widely in the context of immune responses, enabling immune responses to target infectious organisms without harming self-tissues.
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U2 - 10.4049/jimmunol.172.9.5143
DO - 10.4049/jimmunol.172.9.5143
M3 - Short survey
C2 - 15100249
AN - SCOPUS:2142750917
SN - 0022-1767
VL - 172
SP - 5143
EP - 5148
JO - Journal of Immunology
JF - Journal of Immunology
IS - 9
ER -