Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors

H. Wessells, V. J. Hruby, J. Hackett, G. Han, P. Balse-Srinivasan, T. W. Vanderah

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Penile erection induced by α-melanocyte-stimulating hormone and melanocortin receptors (MC-R) in areas of the spinal cord and periphery has not been demonstrated. To elucidate sites of the proerectile action of melanocortin peptides, in awake male rats we administered the MC-R agonist Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 (MT-II) i.c.v., intrathecal ( and i.v. and scored penile erection and yawning. Injection of the MC-R antagonist Ac-Nle-c[Asp-His-DNal(2′)-Arg-Trp-Lys]-NH2 (SHU-9119) i.c.v. or in combination with MT-II differentiated spinal from supraspinal effects. To exclude a site of action in the penis, we recorded intracavernous pressure responses to intracavernosal injection of MT-II in the anesthetized rat. I.c.v.,, and i.v. MT-II induced penile erections in a dose-dependent fashion. Yawning was observed with i.c.v. and i.v. MT-II, while spinal injection did not produce this behavior. Intrathecal delivery of MT-II to the lumbosacral spinal cord was more efficacious in inducing erections than i.c.v. or i.v. administration; SHU-9119 blocked the erectile responses to MT-II when injected but not i.c.v. Intracavernosal MT-II neither increased intracavernous pressure nor augmented neurostimulated erectile responses. We confirmed the central proerectile activity of MT-II and demonstrated that in addition to a site of action in the brain, the distal spinal cord contains melanocortin receptors that can initiate penile erection independent of higher centers. These results provide new insight into the central melanocortinergic pathways that mediate penile erection and may allow for more efficacious melanotropin-based therapy for erectile dysfunction.

Original languageEnglish (US)
Pages (from-to)755-762
Number of pages8
Issue number3
StatePublished - May 25 2003


  • MSH
  • MT-II
  • Rats
  • SHU-9119
  • Sex behavior
  • Spinal cord

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors'. Together they form a unique fingerprint.

Cite this