Aqueous and ethanol extracts of human, rhesus monkey and bovine esophageal mucosa were studied by inhibition of indirect I.F. staining of intercellular areas of the homologous tissues with autoantibodies found in the sera of patients with active pemphigus. These studies revealed that both aqueous and ethanol extracts contain antigen (s) reactive with these autoantibodies. Comparable ethanol extracts of gastric mucosa, kidney, liver, or spleen did not contain demonstrable levels of the active antigen(s). Thermostability studies of the ethanol soluble fractions suggest that they were either partially or completely inactivated in 10 min at 100°C.
ASJC Scopus subject areas
- Immunology and Allergy