Absence of hepatitis B and C viruses in pediatric idiopathic membranoproliferative glomerulonephritis

Michael J. Nowicki; Thomas R. Welch; Nafees Ahmad; I. Kenneth Kuramoto; Eleanor C. Mendoza; Jerome B. Zeldis; Bahige M. Baroudy; William F. Balistreri

doi:10.1007/BF00858957

Absence of hepatitis B and C viruses in pediatric idiopathic membranoproliferative glomerulonephritis

Michael J. Nowicki, Thomas R. Welch, Nafees Ahmad, I. Kenneth Kuramoto, Eleanor C. Mendoza, Jerome B. Zeldis, Bahige M. Baroudy, William F. Balistreri

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The blood-borne hepatitis viruses, hepatitis B virus (HBV) and hepatitis C virus (HCV), have similar epidemiological features. The association of chronic HBV infection and glomerulonephritis is well established, particularly in children. Recent reports have shown an association between HCV infection and glomerulonephritis in adults. In order to assess the role of these hepatotropic viruses in membranoproliferative glomerulonephritis (MPGN) we screened 34 children with idiopathic MPGN for the presence of HBV and HCV infection using highly sensitive polymerase chain reaction techniques for the detection of HBV DNA and HCV RNA. Also, enzyme-linked immunosorbent assays were used to detect the presence of antibody to hepatitis B surface antigen and antibody to HCV. No evidence of HBV or HCV infection was demonstrated in any of the patients. We conclude that HBV and HCV are not significant causes of idiopathic MPGN in children in the United States.

Original language	English (US)
Pages (from-to)	16-18
Number of pages	3
Journal	Pediatric Nephrology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1007/BF00858957
State	Published - Feb 1995
Externally published	Yes

Keywords

Hepatitis B virus
Hepatitis C virus
Idiopathic membranoproliferative glomerulonephritis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Nephrology

Access to Document

10.1007/BF00858957

Cite this

@article{d41dc942a55749aa9021f35570cdf93f,

title = "Absence of hepatitis B and C viruses in pediatric idiopathic membranoproliferative glomerulonephritis",

abstract = "The blood-borne hepatitis viruses, hepatitis B virus (HBV) and hepatitis C virus (HCV), have similar epidemiological features. The association of chronic HBV infection and glomerulonephritis is well established, particularly in children. Recent reports have shown an association between HCV infection and glomerulonephritis in adults. In order to assess the role of these hepatotropic viruses in membranoproliferative glomerulonephritis (MPGN) we screened 34 children with idiopathic MPGN for the presence of HBV and HCV infection using highly sensitive polymerase chain reaction techniques for the detection of HBV DNA and HCV RNA. Also, enzyme-linked immunosorbent assays were used to detect the presence of antibody to hepatitis B surface antigen and antibody to HCV. No evidence of HBV or HCV infection was demonstrated in any of the patients. We conclude that HBV and HCV are not significant causes of idiopathic MPGN in children in the United States.",

keywords = "Hepatitis B virus, Hepatitis C virus, Idiopathic membranoproliferative glomerulonephritis",

author = "Nowicki, {Michael J.} and Welch, {Thomas R.} and Nafees Ahmad and Kuramoto, {I. Kenneth} and Mendoza, {Eleanor C.} and Zeldis, {Jerome B.} and Baroudy, {Bahige M.} and Balistreri, {William F.}",

year = "1995",

month = feb,

doi = "10.1007/BF00858957",

language = "English (US)",

volume = "9",

pages = "16--18",

journal = "Pediatric Nephrology",

issn = "0931-041X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "1",

}

TY - JOUR

T1 - Absence of hepatitis B and C viruses in pediatric idiopathic membranoproliferative glomerulonephritis

AU - Nowicki, Michael J.

AU - Welch, Thomas R.

AU - Ahmad, Nafees

AU - Kuramoto, I. Kenneth

AU - Mendoza, Eleanor C.

AU - Zeldis, Jerome B.

AU - Baroudy, Bahige M.

AU - Balistreri, William F.

PY - 1995/2

Y1 - 1995/2

N2 - The blood-borne hepatitis viruses, hepatitis B virus (HBV) and hepatitis C virus (HCV), have similar epidemiological features. The association of chronic HBV infection and glomerulonephritis is well established, particularly in children. Recent reports have shown an association between HCV infection and glomerulonephritis in adults. In order to assess the role of these hepatotropic viruses in membranoproliferative glomerulonephritis (MPGN) we screened 34 children with idiopathic MPGN for the presence of HBV and HCV infection using highly sensitive polymerase chain reaction techniques for the detection of HBV DNA and HCV RNA. Also, enzyme-linked immunosorbent assays were used to detect the presence of antibody to hepatitis B surface antigen and antibody to HCV. No evidence of HBV or HCV infection was demonstrated in any of the patients. We conclude that HBV and HCV are not significant causes of idiopathic MPGN in children in the United States.

AB - The blood-borne hepatitis viruses, hepatitis B virus (HBV) and hepatitis C virus (HCV), have similar epidemiological features. The association of chronic HBV infection and glomerulonephritis is well established, particularly in children. Recent reports have shown an association between HCV infection and glomerulonephritis in adults. In order to assess the role of these hepatotropic viruses in membranoproliferative glomerulonephritis (MPGN) we screened 34 children with idiopathic MPGN for the presence of HBV and HCV infection using highly sensitive polymerase chain reaction techniques for the detection of HBV DNA and HCV RNA. Also, enzyme-linked immunosorbent assays were used to detect the presence of antibody to hepatitis B surface antigen and antibody to HCV. No evidence of HBV or HCV infection was demonstrated in any of the patients. We conclude that HBV and HCV are not significant causes of idiopathic MPGN in children in the United States.

KW - Hepatitis B virus

KW - Hepatitis C virus

KW - Idiopathic membranoproliferative glomerulonephritis

UR - http://www.scopus.com/inward/record.url?scp=0028876851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028876851&partnerID=8YFLogxK

U2 - 10.1007/BF00858957

DO - 10.1007/BF00858957

M3 - Article

C2 - 7742214

AN - SCOPUS:0028876851

SN - 0931-041X

VL - 9

SP - 16

EP - 18

JO - Pediatric Nephrology

JF - Pediatric Nephrology

IS - 1

ER -

Absence of hepatitis B and C viruses in pediatric idiopathic membranoproliferative glomerulonephritis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this