A tool for multiple sequence alignment

D. J. Lipman, S. F. Altschul, J. D. Kececioglu

Research output: Contribution to journalArticlepeer-review

365 Scopus citations


Multiple sequence alignment can be a useful technique for studying molecular evolution and analyzing sequence-structure relationships. Until recently, it has been impractical to apply dynamic programming, the most widely accepted method for producing pairwise alignments, to comparisons of more than three sequences. We describe the design and application of a tool for multiple alignment of amino acid sequences that implements a new algorithm that greatly reduces the computational demands of dynamic programming. This tool is able to align in reasonable time as many as eight sequences the length of an average protein.

Original languageEnglish (US)
Pages (from-to)4412-4415
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number12
StatePublished - 1989

ASJC Scopus subject areas

  • General


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