A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.

Robin Polt; Yushun Li; Quintus Fernando; Mario Rivera

doi:10.1016/S0040-4039(00)79572-4

A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.

Robin Polt
, Yushun Li
, Quintus Fernando
, Mario Rivera

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesized the DMSA-bis-disulfide using novel methodology based on the use of sulfenimides derived from cysteine.

Original language	English (US)
Pages (from-to)	2961-2964
Number of pages	4
Journal	Tetrahedron Letters
Volume	33
Issue number	21
DOIs	https://doi.org/10.1016/S0040-4039(00)79572-4
State	Published - May 19 1992

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.",

abstract = "meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesized the DMSA-bis-disulfide using novel methodology based on the use of sulfenimides derived from cysteine.",

author = "Robin Polt and Yushun Li and Quintus Fernando and Mario Rivera",

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T1 - A synthetic method for unsymmetrical disulfides of cysteine

T2 - the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.

AU - Polt, Robin

AU - Li, Yushun

AU - Fernando, Quintus

AU - Rivera, Mario

PY - 1992/5/19

Y1 - 1992/5/19

N2 - meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesized the DMSA-bis-disulfide using novel methodology based on the use of sulfenimides derived from cysteine.

AB - meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesized the DMSA-bis-disulfide using novel methodology based on the use of sulfenimides derived from cysteine.

UR - https://www.scopus.com/pages/publications/0026710936

UR - https://www.scopus.com/pages/publications/0026710936#tab=citedBy

U2 - 10.1016/S0040-4039(00)79572-4

DO - 10.1016/S0040-4039(00)79572-4

M3 - Article

AN - SCOPUS:0026710936

SN - 0040-4039

VL - 33

SP - 2961

EP - 2964

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 21

ER -

A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.

Abstract

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