A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.

Robin Polt; Yushun Li; Quintus Fernando; Mario Rivera

doi:10.1016/S0040-4039(00)79572-4

A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.

Robin Polt, Yushun Li, Quintus Fernando, Mario Rivera

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesized the DMSA-bis-disulfide using novel methodology based on the use of sulfenimides derived from cysteine.

Original language	English (US)
Pages (from-to)	2961-2964
Number of pages	4
Journal	Tetrahedron Letters
Volume	33
Issue number	21
DOIs	https://doi.org/10.1016/S0040-4039(00)79572-4
State	Published - May 19 1992

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(00)79572-4

Cite this

@article{3fd4c0e6f7df4e28a77ef438a6c39eb1,

title = "A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.",

abstract = "meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesized the DMSA-bis-disulfide using novel methodology based on the use of sulfenimides derived from cysteine.",

author = "Robin Polt and Yushun Li and Quintus Fernando and Mario Rivera",

year = "1992",

month = may,

day = "19",

doi = "10.1016/S0040-4039(00)79572-4",

language = "English (US)",

volume = "33",

pages = "2961--2964",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "21",

}

TY - JOUR

T1 - A synthetic method for unsymmetrical disulfides of cysteine

T2 - the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.

AU - Polt, Robin

AU - Li, Yushun

AU - Fernando, Quintus

AU - Rivera, Mario

PY - 1992/5/19

Y1 - 1992/5/19

N2 - meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesized the DMSA-bis-disulfide using novel methodology based on the use of sulfenimides derived from cysteine.

AB - meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesized the DMSA-bis-disulfide using novel methodology based on the use of sulfenimides derived from cysteine.

UR - http://www.scopus.com/inward/record.url?scp=0026710936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026710936&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)79572-4

DO - 10.1016/S0040-4039(00)79572-4

M3 - Article

AN - SCOPUS:0026710936

SN - 0040-4039

VL - 33

SP - 2961

EP - 2964

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 21

ER -

A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this