TY - JOUR
T1 - A study of the human immune response to Lolium perenne (Rye) pollen and its components, Lol p I and Lol p II (Rye I and Rye II). I. Prevalence of reactivity to the allergens and correlations among skin test, IgE antibody, and IgG antibody data
AU - Freidhoff, Linda R.
AU - Ehrlich-Kautzky, Eva
AU - Grant, John H.
AU - Meyers, Deborah A.
AU - Marsh, David G.
N1 - Funding Information:
From the Division of Clinical Immunology, The Johns Hopkins University School of Medicine, at The Good SamaritanH ospital, Baltimore, Md. Supported by National Institutes of Health Grants AI-19727 and AI-20059. Received for publication Dec. 30, 1985. Accepted for publication May 17, 1986. Reprint requests:L inda Freidhoff, M.S., Good SamaritanH ospital, 5601 Loch Raven Blvd., Baltimore, MD 21239. *Publication No. 646 from the O’Neill ResearchL aboratories,The Good Samaritan Hospital, Baltimore, Md.
PY - 1986/12
Y1 - 1986/12
N2 - In a stratified random sample of 320 white adults, the prevalence of puncture skin test positivity (ST+) to Lolium perenne (rye grass)-pollen extract (LPE) was 16%. Fifteen percent of all subjects (or 84% of subjects classified LPE IgE antibody positive [Ab+]) was classified IgE Ab+ to highly purified Lol p I (Rye I), and 4% of all subjects (or 26% of subjects classified LPE IgE Ah+) was classified IgE Ab+ to highly purified Lol p II (Rye II). These data and similar results obtained in an allergy-enriched group of 361 subjects are consistent with previous studies that Lol I is a major allergen and Lol II is a minor allergen of LPE. Whether we studied LPE, Lol I, or Lol II, responder subjects were younger than nonresponder subjects and more male than female subjects were responders. We then investigated the quantitative interrelationships among ST, IgE, and IgG Ab responsiveness to LPE, Lol I, and Lol II in the allergy-enriched group. For each allergen, log-log correlations were strong and significant for ST versus IgE Ab and for IgE Ab versus IgG Ab. All subjects IgE Ab + to Lol I or Lol II were IgG Ab+ to that allergen, supporting other evidence for a commonality in the genetic control influencing the production of IgE and IgG Abs to a given allergen. Log-log correlations among ST end points, IgE Ab levels, or IgG Ab levels were strong for LPE versus either Lol I or Lol II but weak between Lol I and Lol II, consistent with the reported lack of cross-reactivity between Lol I and Lol II. Despite these findings, almost all Lol II+ subjects were Lol I+ by ST (98%), IgE Ab (91%), and IgG Ab (83%), suggesting that the Ia-restricted immune recognition of both these molecules is at least in part under a common genetic control.
AB - In a stratified random sample of 320 white adults, the prevalence of puncture skin test positivity (ST+) to Lolium perenne (rye grass)-pollen extract (LPE) was 16%. Fifteen percent of all subjects (or 84% of subjects classified LPE IgE antibody positive [Ab+]) was classified IgE Ab+ to highly purified Lol p I (Rye I), and 4% of all subjects (or 26% of subjects classified LPE IgE Ah+) was classified IgE Ab+ to highly purified Lol p II (Rye II). These data and similar results obtained in an allergy-enriched group of 361 subjects are consistent with previous studies that Lol I is a major allergen and Lol II is a minor allergen of LPE. Whether we studied LPE, Lol I, or Lol II, responder subjects were younger than nonresponder subjects and more male than female subjects were responders. We then investigated the quantitative interrelationships among ST, IgE, and IgG Ab responsiveness to LPE, Lol I, and Lol II in the allergy-enriched group. For each allergen, log-log correlations were strong and significant for ST versus IgE Ab and for IgE Ab versus IgG Ab. All subjects IgE Ab + to Lol I or Lol II were IgG Ab+ to that allergen, supporting other evidence for a commonality in the genetic control influencing the production of IgE and IgG Abs to a given allergen. Log-log correlations among ST end points, IgE Ab levels, or IgG Ab levels were strong for LPE versus either Lol I or Lol II but weak between Lol I and Lol II, consistent with the reported lack of cross-reactivity between Lol I and Lol II. Despite these findings, almost all Lol II+ subjects were Lol I+ by ST (98%), IgE Ab (91%), and IgG Ab (83%), suggesting that the Ia-restricted immune recognition of both these molecules is at least in part under a common genetic control.
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U2 - 10.1016/0091-6749(86)90271-X
DO - 10.1016/0091-6749(86)90271-X
M3 - Article
C2 - 3782681
AN - SCOPUS:0022891761
SN - 0091-6749
VL - 78
SP - 1190
EP - 1201
JO - The Journal of Allergy and Clinical Immunology
JF - The Journal of Allergy and Clinical Immunology
IS - 6
ER -