A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine

Kevin A. Scott; M. Haziq Qureshi; Philip B. Cox; Christopher M. Marshall; Bailey C. Bellaire; Michael Wilcox; Bradey A.R. Stuart; Jon T. Njardarson

doi:10.1021/acs.jmedchem.0c01502

A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine

Kevin A. Scott, M. Haziq Qureshi, Philip B. Cox, Christopher M. Marshall, Bailey C. Bellaire, Michael Wilcox, Bradey A.R. Stuart, Jon T. Njardarson

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

The FDA Green Book is a list of all drug products that have been approved by the FDA for use in veterinary medicine. The Green Book, as published, lacks structural information corresponding to approved drugs. To address this gap, we have compiled the structural data for all FDA Green Book drugs approved through the end of 2019. Herein we discuss the relevance of this data set to human drugs in the context of structural classes and physicochemical properties. Analysis reveals that physicochemical properties are highly optimized and consistent with a high probability of favorable drug metabolism and pharmacokinetic properties, including good oral bioavailability for most compounds. We provide a detailed analysis of this data set organized on the basis of structure and function. Slightly over half (51%) of vet drugs are also approved in human medicine. Combination drugs are biologics are also discussed.

Original language	English (US)
Pages (from-to)	15449-15482
Number of pages	34
Journal	Journal of Medicinal Chemistry
Volume	63
Issue number	24
DOIs	https://doi.org/10.1021/acs.jmedchem.0c01502
State	Published - Dec 24 2020
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1021/acs.jmedchem.0c01502

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abstract = "The FDA Green Book is a list of all drug products that have been approved by the FDA for use in veterinary medicine. The Green Book, as published, lacks structural information corresponding to approved drugs. To address this gap, we have compiled the structural data for all FDA Green Book drugs approved through the end of 2019. Herein we discuss the relevance of this data set to human drugs in the context of structural classes and physicochemical properties. Analysis reveals that physicochemical properties are highly optimized and consistent with a high probability of favorable drug metabolism and pharmacokinetic properties, including good oral bioavailability for most compounds. We provide a detailed analysis of this data set organized on the basis of structure and function. Slightly over half (51%) of vet drugs are also approved in human medicine. Combination drugs are biologics are also discussed.",

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AU - Bellaire, Bailey C.

AU - Wilcox, Michael

AU - Stuart, Bradey A.R.

AU - Njardarson, Jon T.

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AB - The FDA Green Book is a list of all drug products that have been approved by the FDA for use in veterinary medicine. The Green Book, as published, lacks structural information corresponding to approved drugs. To address this gap, we have compiled the structural data for all FDA Green Book drugs approved through the end of 2019. Herein we discuss the relevance of this data set to human drugs in the context of structural classes and physicochemical properties. Analysis reveals that physicochemical properties are highly optimized and consistent with a high probability of favorable drug metabolism and pharmacokinetic properties, including good oral bioavailability for most compounds. We provide a detailed analysis of this data set organized on the basis of structure and function. Slightly over half (51%) of vet drugs are also approved in human medicine. Combination drugs are biologics are also discussed.

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A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine

Abstract

ASJC Scopus subject areas

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