A sliding selectivity scale for lipid binding to membrane proteins

Michael Landreh, Michael T. Marty, Joseph Gault, Carol V. Robinson

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Biological membranes form barriers that are essential for cellular integrity and compartmentalisation. Proteins in the membrane have co-evolved with their hydrophobic lipid environment, which serves as a solvent for proteins with very diverse requirements. As a result, their interactions range from non-selective to highly discriminating. Mass spectrometry enables us to monitor how lipids interact with membrane proteins and assess their effects on structure and dynamics. Recent studies illustrate the ability to differentiate specific lipid binding, preferential interactions with lipid subsets, and nonselective annular contacts. Here, we consider the biological implications of different lipid-binding scenarios and propose that binding occurs on a sliding selectivity scale, in line with the view of biological membranes as facilitators of dynamic protein and lipid organization.

Original languageEnglish (US)
Pages (from-to)54-60
Number of pages7
JournalCurrent Opinion in Structural Biology
StatePublished - Aug 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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