Abstract
Purpose: To develop a high-speed T2 mapping protocol that is capable of accurately measuring T2 relaxation time constants from a single-shot acquisition. Theory: A new echo-split single-shot gradient-spin-echo (GRASE) pulse sequence is developed to acquire multicontrast data while suppressing signals from most nonprimary echo pathways in Carr-Purcell-Meiboom-Gill (CPMG) echoes. Residual nonprimary pathway signals are taken into consideration when performing T2 mapping using a parametric multiplexed sensitivity encoding based on projection onto convex sets (parametric-POCSMUSE) reconstruction method that incorporates extended phase graph modeling of GRASE signals. Methods: The single-shot echo-split GRASE-based T2 mapping procedure was evaluated in human studies at 3 Tesla. The acquired data were compared with reference data obtained with a more time-consuming interleaved spin-echo echo planar imaging protocol. T2 maps derived from conventional single-shot GRASE scans, in which nonprimary echo pathways were not appropriately addressed, were also evaluated. Results: Using the developed single-shot T2 mapping protocol, quantitatively accurate T2 maps can be obtained with a short scan time (<0.2 seconds per slice). Conclusion: Accurate T2 mapping with minimal signal contamination from CPMG high-order echo pathways can be achieved by the developed method that integrates single-shot echo-split GRASE acquisition and parametric-POCSMUSE reconstruction. Magn Reson Med 79:383–393, 2018.
Original language | English (US) |
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Pages (from-to) | 383-393 |
Number of pages | 11 |
Journal | Magnetic Resonance in Medicine |
Volume | 79 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2018 |
Keywords
- GRASE
- T mapping
- echo-split GRASE
- extended phase graph analysis
- parametric-POCSMUSE
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging