A single exercise bout augments adenovirus-specific T-cell mobilization and function

Hawley E. Kunz, Guillaume Spielmann, Nadia H. Agha, Daniel P. O'Connor, Catherine M. Bollard, Richard J. Simpson

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Adoptive transfer of virus-specific T-cells (VSTs) effectively treats viral infections following allogeneic hematopoietic stem cell transplantation (alloHSCT), but logistical difficulties have limited widespread availability of VSTs as a post-transplant therapeutic. A single exercise bout mobilizes VSTs specific for latent herpesviruses (i.e. CMV and EBV) to peripheral blood and augments their ex vivo expansion. We investigated whether exercise exerts similar effects on T-cells specific for a NON-latent virus such as adenovirus, which is a major contributor to infection-related morbidity and mortality after alloHSCT. Thirty minutes of cycling exercise increased circulating adenovirus-specific T-cells 2.0-fold and augmented their ex vivo expansion by ~33% compared to rest without altering antigen and MHC-specific autologous target cell killing capabilities. We conclude that exercise is a simple and economical adjuvant to boost the isolation and manufacture of therapeutic VSTs specific to latent and non-latent viruses from healthy donors.

Original languageEnglish (US)
Pages (from-to)56-65
Number of pages10
JournalPhysiology and Behavior
StatePublished - Oct 1 2018


  • Acute stress response
  • Adoptive transfer immunotherapy
  • Allogeneic hematopoietic stem cell transplantation
  • ex vivo expansion
  • Exercise immunology
  • Viral infections

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience


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