Abstract
(Figure Presented) Branch point: A simple primary amine thiourea catalyzed highly enantioselective conjugate addition of α,α-disubstituted aldehydes to maleimides has been developed. The biologically useful chiral disubstituted α-branched succinimides are attained with the generation of two contiguous quaternary and/or tertiary stereogenic centers in one step with excellent enantioselectivities and in high yields under mild reaction conditions (see scheme).
Original language | English (US) |
---|---|
Pages (from-to) | 7979-7982 |
Number of pages | 4 |
Journal | Chemistry - A European Journal |
Volume | 16 |
Issue number | 27 |
DOIs | |
State | Published - Jul 19 2010 |
Externally published | Yes |
Keywords
- Aldehydes
- Maleimides
- Michael addition
- Organocatalysis
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry