A simple method for NMR t₁ noise suppression

t₁ noise appears as random or semi-random spurious streaks along the indirect t₁ (F1) dimension of a 2D or nD NMR spectrum. It can significantly downgrade spectral quality, especially for spectra with strong diagonal signals such as NOESY, because useful and weak cross-peaks can be easily buried under t₁ noise. One of the significant contributing factors to t₁ noise is unwanted and semi-random F2 signal modulation during t₁ acquisition. As such, t₁ noise from different acquisitions is unlikely to correlate with each other strongly. In the case of NOESY, co-addition of multiple spectra significantly reduces t₁ noise compared with conventional acquisition with the same amount of total acquisition time and resolution.