A simple method for NMR t1 noise suppression

Huaping Mo, John S. Harwood, Danzhou Yang, Carol Beth Post

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


t1 noise appears as random or semi-random spurious streaks along the indirect t1 (F1) dimension of a 2D or nD NMR spectrum. It can significantly downgrade spectral quality, especially for spectra with strong diagonal signals such as NOESY, because useful and weak cross-peaks can be easily buried under t1 noise. One of the significant contributing factors to t1 noise is unwanted and semi-random F2 signal modulation during t1 acquisition. As such, t1 noise from different acquisitions is unlikely to correlate with each other strongly. In the case of NOESY, co-addition of multiple spectra significantly reduces t1 noise compared with conventional acquisition with the same amount of total acquisition time and resolution.

Original languageEnglish (US)
Pages (from-to)43-50
Number of pages8
JournalJournal of Magnetic Resonance
StatePublished - Mar 1 2017


  • 2D spectroscopy
  • Frequency fluctuation
  • NMR
  • t noise suppression

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics


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