A simple, cheap alternative to 'designer convertible isonitriles' expedited with microwaves

Christopher Hulme; Shashi Chappeta; Justin Dietrich

doi:10.1016/j.tetlet.2009.04.095

A simple, cheap alternative to 'designer convertible isonitriles' expedited with microwaves

Christopher Hulme
, Shashi Chappeta
, Justin Dietrich

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Interest in designer convertible isonitriles has increased in recent years with the growing recognition that isonitrile-based multi-component reactions (IMCRs) are highly effective in rapidly accessing, new and pharmacologically relevant diversity space. This Letter reports on the novel use of n-butylisonitrile as a cheaper and more atom-economical alternative to currently reported 'designer convertible isonitriles', facilitated by the advent of microwave-assisted organic synthesis (MAOS).

Original language	English (US)
Pages (from-to)	4054-4057
Number of pages	4
Journal	Tetrahedron Letters
Volume	50
Issue number	28
DOIs	https://doi.org/10.1016/j.tetlet.2009.04.095
State	Published - Jul 15 2009

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2009.04.095

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abstract = "Interest in designer convertible isonitriles has increased in recent years with the growing recognition that isonitrile-based multi-component reactions (IMCRs) are highly effective in rapidly accessing, new and pharmacologically relevant diversity space. This Letter reports on the novel use of n-butylisonitrile as a cheaper and more atom-economical alternative to currently reported 'designer convertible isonitriles', facilitated by the advent of microwave-assisted organic synthesis (MAOS).",

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AB - Interest in designer convertible isonitriles has increased in recent years with the growing recognition that isonitrile-based multi-component reactions (IMCRs) are highly effective in rapidly accessing, new and pharmacologically relevant diversity space. This Letter reports on the novel use of n-butylisonitrile as a cheaper and more atom-economical alternative to currently reported 'designer convertible isonitriles', facilitated by the advent of microwave-assisted organic synthesis (MAOS).

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JO - Tetrahedron Letters

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A simple, cheap alternative to 'designer convertible isonitriles' expedited with microwaves

Abstract

ASJC Scopus subject areas

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