A role for glia in the development of organized neuropilar structures

Leslie P Tolbert, Lynne A. Oland

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations


Intercellular interactions are critical in the development of the nervous system. In the olfactory system of a moth, sensory axons induce the formation of large synaptic glomeruli, each surrounded by a glial envelope, in the antennal lobe of the brain. During development, the sensory axons cause changes in glial shape and disposition one day before glomeruli are recognized. Early removal of glial cells prevents the development of glomeruli despite the presence of afferent axons. Thus, the glial cells appear to play a role as intermediaries in the induction of glomeruli by afferent axons. Recent findings in the mammalian somatosensory cortex suggest a similar role for glia there.

Original languageEnglish (US)
Pages (from-to)70-75
Number of pages6
JournalTrends in Neurosciences
Issue number2
StatePublished - 1989

ASJC Scopus subject areas

  • General Neuroscience


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