A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion

Longchuan Bai, Juanita L. Merchant

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

A thorough understanding of histone acetyltransferase CBP/p300-mediated regulation of gene expression and cell growth is essential to identify mechanisms relevant to the development of histone deacetylase (HDAC) inhibitor-based preventive and therapeutic strategies. We found that knockdown of CBP/p300 interacting coactivator with glutamic acid/aspartic acid-rich tail 2 (CITED2) increased colon cancer cell invasiveness in vitro. Gene expression profiling revealed that CITED2 knockdown induced matrix metalloproteinase-13 (MMP-13) gene expression in colon cancer cells. Butyrate, a naturally occurring HDAC inhibitor, induced CITED2 expression and downregulated MMP-13 expression in RKO cells. Additionally, ectopic expression of CITED2 arrested RKO cell growth. Thus, CITED2 regulates colon cancer invasion and might be a target for HDAC inhibitor-based intervention of colon cancer.

Original languageEnglish (US)
Pages (from-to)5904-5910
Number of pages7
JournalFEBS Letters
Volume581
Issue number30
DOIs
StatePublished - Dec 22 2007
Externally publishedYes

Keywords

  • β-catenin
  • Butyrate
  • Histone deacetylase inhibitor
  • Matrix metalloproteinase-13

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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